Methods for attaching polymerizable ceragenins to water treatment membranes using silane linkages

Hibbs, Michael; Altman, Susan J.; Jones, Howland D. T.; Savage, Paul B.

Title: Methods for attaching polymerizable ceragenins to water treatment membranes using silane linkages

Patent · Tue Sep 10 00:00:00 EDT 2013

OSTI ID:1092937

Hibbs, Michael; Altman, Susan J.; Jones, Howland D. T.; Savage, Paul B.

This invention relates to methods for chemically grafting and attaching ceragenin molecules to polymer substrates; methods for synthesizing ceragenin-containing copolymers; methods for making ceragenin-modified water treatment membranes and spacers; and methods of treating contaminated water using ceragenin-modified treatment membranes and spacers. Ceragenins are synthetically produced antimicrobial peptide mimics that display broad-spectrum bactericidal activity. Alkene-functionalized ceragenins (e.g., acrylamide-functionalized ceragenins) can be attached to polyamide reverse osmosis membranes using amine-linking, amide-linking, UV-grafting, or silane-coating methods. In addition, silane-functionalized ceragenins can be directly attached to polymer surfaces that have free hydroxyls.

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Research Organization:: Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

Sponsoring Organization:: USDOE

DOE Contract Number:: AC04-94AL85000

Assignee:: Sandia Corporation (Albuquerque, NM)

Patent Number(s):: 8,530,002

Application Number:: 12/986,221

OSTI ID:: 1092937

Country of Publication:: United States

Language:: English

References (14)

Selective membrane having a high fouling resistance Koo, Ja-Young; Hong, Sung-pyo; Lee, Jong-Hwa https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/7537697 US Patent Document 7,537,697	patent	May 2009
Promoting the cytocompatibility of polyurethane scaffolds via surface photo-grafting polymerization of acrylamide Zhu, Yabin; Gao, Changyou; Guan, Jianjun Journal of Materials Science: Materials in Medicine, Vol. 15, Issue 3 https://doi.org/10.1023/B:JMSM.0000015489.27261.f0	journal	March 2004
Steroid derived antibiotics Savage, Paul B.; Li, Chunhong https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/6767904 US Patent Document 6,767,904	patent	July 2004
Cationic steroid antimicrobial compositions and methods of use Savage, Paul B.; Leung, Donald Y. M. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/7754705 US Patent Document 7,754,705	patent	July 2010
Composite membrane with polyalkylene oxide modified polyamide surface Mickols, William E. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/6280853 US Patent Document 6,280,853	patent	August 2001
Functionalized substrates Waller, Jr., Clinton P.; Weiss, Douglas E. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/7553417 US Patent Document 7,553,417	patent	June 2009
Process for improving membranes Belfer, Sophia; Fainstein, Rosalia; Kesselman, Luba https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/7677398 US Patent Document 7,677,398	patent	March 2010
Photoinduced graft polymerization of acrylamide on polypropylene microporous membranes for the improvement of antifouling characteristics in a submerged membrane-bioreactor Yu, H.; Xu, Z.; Lei, H. Separation and Purification Technology, Vol. 53, Issue 1 https://doi.org/10.1016/j.seppur.2006.07.002	journal	February 2007
Peptide Antimicrobial Agents Jenssen, Håvard; Hamill, Pamela; Hancock, Robert E. W. Clinical Microbiology Reviews, Vol. 19, Issue 3 https://doi.org/10.1128/CMR.00056-05	journal	July 2006
Composite membrane and method for making the same Mickols, William E. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/6878278 US Patent Document 6,878,278	patent	April 2005
Membrane which comprises a blend of a polysulphone or a polyether sulphone and polyethylene oxide/polypropylene oxide substituted ethylene diamine Heijnen, Martin https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/6495043 US Patent Document 6,495,043	patent	December 2002
Selective membrane having a high fouling resistance Koo, Ja-Young; Hong, Sung-pyo; Kang, Jin Woo https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/6913694 US Patent Document 6,913,694	patent	July 2005
Cationic Steroid Antibiotics Savage, P. Current Medicinal Chemistry -Anti-Infective Agents, Vol. 1, Issue 3 https://doi.org/10.2174/1568012023354776	journal	July 2002
Polyamide membrane with coating of polyalkylene oxide and polyacrylamide compounds Mickols, William E.; Zhang, Chunming https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/7815987 US Patent Document 7,815,987	patent	October 2010

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