VPS26 Moonlights as an Arrestin-like Adapter for a 7-transmembrane RGS 2 protein in Arabidopsis thaliana
Extracellular signals perceived by 7-transmembrane (7TM)-spanning receptors on the plasma membrane utilize a cytoplasmic adaptor that propagates signaling and initiates a feedback circuit for desensitization by removal of these receptors at the plasma membrane leading to desensitization to that signal. Signal (agonist) binding often evokes phosphorylation at the C-terminal tail of many 7TM G-protein-coupled receptors in animal cells which then recruits a cytoplasmic intermediate adaptor, β-arrestin, that sets in motion clathrin-mediated endocytosis (CME). Some 7TM receptors have agonist-induced phosphorylation and CME that do not involve β-arrestin, therefore it is unclear how these phosphorylated 7TM receptors are internalized. Arrestins, neither α–more »