Isotherm parameters and intraparticle mass transfer kinetics on molecularly imprinted polymers in acetonitrile/buffer mobile phases

Journal Article · Wed Mar 01 00:00:00 EST 2006 · Chemical Engineering Science

DOI:https://doi.org/10.1016/j.ces.2006.03.043· OSTI ID:989616

Kim, Hyunjung ^[1]; Kaczmarski, Krzysztof ^[2]; Guiochon, Georges A ^[3]

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1. University of Tennessee, Knoxville (UTK)
2. University of Tennessee and Rzeszow University of Technology, Poland
3. ORNL

The equilibrium isotherm and the intraparticle mass transfer kinetics of the enantiomers of the template were investigated on an Fmoc-L-tryptophan (Fmoc-L-Trp) imprinted polymer at different pHs and water concentrations in acetonitrile/aqueous buffer mobile phases. The equilibrium isotherm data were measured using frontal analysis at 25 {+-} 2 C. The adsorption energy distribution was found to be trimodal, with narrow modes. Consistent with this distribution, the adsorption data were modeled using a tri-Langmuir isotherm equation and the best estimates of the isotherm parameters were determined. The intraparticle mass transfer parameters were derived by comparing the profiles of experimental overloaded bands and the profiles calculated using the isotherm model and the lumped pore diffusion (POR) model of chromatography. These results showed that different adsorption and mass transfer mechanisms exist in mobile phases made of acetonitrile/aqueous buffer and of acetonitrile/acetic acid solutions.

• Research Organization: Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
• Sponsoring Organization: USDOE Office of Science (SC)
• DOE Contract Number: DE-AC05-00OR22725
• OSTI ID: 989616
• Journal Information: Chemical Engineering Science, Vol. 61, Issue 2006; ISSN 0009-2509
• Country of Publication: United States
• Language: English

Related Subjects

37 INORGANIC
ORGANIC
PHYSICAL AND ANALYTICAL CHEMISTRY
42 ENGINEERING
36 MATERIALS SCIENCE
ADSORPTION
BUFFERS
CHROMATOGRAPHY
DIFFUSION
DISTRIBUTION
ENERGY SPECTRA
ISOTHERMS
KINETICS
MASS TRANSFER
POLYMERS
WATER
Fmoc-L-tryptophan imprinted polymers
frontal analysis
isotherm parameters
intraparticle mass transfer kinetics
acetonitrile/buffer solutions
PH
amount of water