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Title: Nucleic acid detection compositions

The present invention relates to means for the detection and characterization of nucleic acid sequences, as well as variations in nucleic acid sequences. The present invention also relates to methods for forming a nucleic acid cleavage structure on a target sequence and cleaving the nucleic acid cleavage structure in a site-specific manner. The structure-specific nuclease activity of a variety of enzymes is used to cleave the target-dependent cleavage structure, thereby indicating the presence of specific nucleic acid sequences or specific variations thereof.
Authors:
 [1] ;  [1] ;  [1] ;  [1] ;  [1]
  1. Madison, WI
Publication Date:
OSTI Identifier:
985508
Report Number(s):
7,407,782
US patent application; TRN: US201016%%2030
DOE Contract Number:
FG02-94ER81891
Resource Type:
Patent
Research Org:
Third Wave Technologies, Inc. (Madison, WI)
Sponsoring Org:
USDOE
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; CLEAVAGE; DETECTION; ENZYMES; INVENTIONS; NUCLEASES; NUCLEIC ACIDS; TARGETS