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Title: Mutator gene and hereditary non-polyposis colorectal cancer

The human MSH2 gene, responsible for hereditary non-polyposis colorectal cancer, was identified by virtue of its homology to the MutS class of genes, which are involved in DNA mismatch repair. The sequence of cDNA clones of the human gene are provided, and the sequence of the gene can be used to demonstrate the existence of germ line mutations in hereditary non-polyposis colorectal cancer (HNPCC) kindreds, as well as in replication error.sup.+ (RER.sup.+) tumor cells.
Authors:
 [1] ;  [2] ;  [2]
  1. Helsingfors, FI
  2. Baltimore, MD
Publication Date:
OSTI Identifier:
983105
Report Number(s):
7,326,778
US patent application 08/160,295
DOE Contract Number:
FG02-91ER61139
Resource Type:
Patent
Research Org:
ELEANOR ROOSEVELT INSTITUTE
Sponsoring Org:
USDOE
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES