Constraint of DNA on Functionalized Graphene Improves Its Biostability and Specificity
Journal Article
·
· Small, 6(11):1205-1209
The single-stranded DNA constrained on graphene surface is effectively protected from enzymatic cleavage by DNase I. The anisotropy, fluorescence, NMR, and CD studies suggest that the single-stranded DNA is promptly adsorbed onto graphene forming strong molecular interactions. Furthermore, the constraint of DNA probe on graphene improves the specificity of its response to complementary DNA. These findings will promote the further application of graphene in biotechnology and biomedical fields.
- Research Organization:
- Pacific Northwest National Lab. (PNNL), Richland, WA (United States). Environmental Molecular Sciences Lab. (EMSL)
- Sponsoring Organization:
- USDOE
- DOE Contract Number:
- AC05-76RL01830
- OSTI ID:
- 982955
- Report Number(s):
- PNNL-SA-67870; 24822; TRN: US201014%%141
- Journal Information:
- Small, 6(11):1205-1209, Vol. 6, Issue 11
- Country of Publication:
- United States
- Language:
- English
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