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Title: Identification of M-CSF agonists and antagonists

Patent ·
OSTI ID:982807
 [1];  [2];  [3];  [4];  [5];  [6];  [6];  [7];  [8]
  1. Mystic, CT
  2. Walnut Creek, CA
  3. Moraga, CA
  4. El Cerrito, CA
  5. San Rafael, CA
  6. Oakland, CA
  7. Martinez, CA
  8. Armonk, NY
+ Show Author Affiliations

The present invention is directed to methods for crystallizing macrophage colony stimulating factor. The present invention is also directed to methods for designing and producing M-CSF agonists and antagonists using information derived from the crystallographic structure of M-CSF. The invention is also directed to methods for screening M-CSF agonists and antagonists. In addition, the present invention is directed to an isolated, purified, soluble and functional M-CSF receptor.

Research Organization:
Univ. of California (United States)
Sponsoring Organization:
USDOE
DOE Contract Number:
AC03-76SF00098
Assignee:
Chiron Corporation (Emeryville, CA)
Patent Number(s):
6,025,146
Application Number:
08/462,069
OSTI ID:
982807
Country of Publication:
United States
Language:
English

References (3)

Three-dimensional structure of dimeric human recombinant macrophage colony-stimulating factor journal November 1992
Australian Mutual Provident Society v 400 St Kilda Road Pty Ltd journal August 1989
Structure-function studies on recombinant human macrophage colony-stimulating factor (M-CSF). journal December 1994

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Related Subjects

59 BASIC BIOLOGICAL SCIENCES