Modeling high gradient magnetic separation from biological fluids.
A proposed portable magnetic separator consists of an array of biocompatible capillary tubing and magnetizable wires immersed in an externally applied homogeneous magnetic field. While subject to the homogeneous magnetic field, the wires create high magnetic field gradients, which aid in the collection of blood-borne magnetic nanospheres from blood flow. In this study, a 3-D numerical model was created using COMSOL Multiphysics 3.2 software to determine the configuration of the wire-tubing array from two possible configurations, one being an array with rows alternating between wires and tubing, and the other being an array where wire and tubing alternate in two directions. The results demonstrated that the second configuration would actually capture more of the magnetic spheres. Experimental data obtained by our group support this numerical result.
- Research Organization:
- Argonne National Lab. (ANL), Argonne, IL (United States)
- Sponsoring Organization:
- Defense Advanced Research Projects Agency (DARPA); Univ. of Chicago Brain Research; Cancer Research Foundations
- DOE Contract Number:
- DE-AC02-06CH11357
- OSTI ID:
- 981636
- Report Number(s):
- ANL/CMT/CP-58163; TRN: US201012%%865
- Resource Relation:
- Conference: COMSOL Users Conference; Oct. 22, 2006 - Oct. 24, 2006; Boston, MA
- Country of Publication:
- United States
- Language:
- ENGLISH
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