Structure of Human DNL Polymerase k Inserting dATP Opposite an 8-OxoG DNA Lesion
The structure we present here is the first for a eukaryotic translesion synthesis (TLS) DNA polymerase with an 8-oxoG:A base pair in the active site. The structure shows why Pol? is more efficient at inserting an A opposite the 8-oxoG lesion than a C. The structure also provides a basis for why Pol? is more efficient at inserting an A opposite the lesion than other Y-family DNA polymerases.
- Research Organization:
- Brookhaven National Lab. (BNL), Upton, NY (United States). National Synchrotron Light Source
- Sponsoring Organization:
- Doe - Office Of Science
- DOE Contract Number:
- DE-AC02-98CH10886
- OSTI ID:
- 980554
- Report Number(s):
- BNL-93472-2010-JA; TRN: US201015%%1939
- Journal Information:
- PLoS One, Vol. 4, Issue 6
- Country of Publication:
- United States
- Language:
- English
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