skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Structural Basis of High-Fidelity DNA Synthesis by Yeast DNA Polymerase δ

Abstract

DNA polymerase ? (Pol ?) has a crucial role in eukaryotic replication. Now the crystal structure of the yeast DNA Pol ? catalytic subunit in complex with template primer and incoming nucleotide is presented at 2.0-A resolution, providing insight into its high fidelity and a framework to understand the effects of mutations involved in tumorigenesis.

Authors:
; ; ; ;
Publication Date:
Research Org.:
Brookhaven National Lab. (BNL), Upton, NY (United States). National Synchrotron Light Source
Sponsoring Org.:
Doe - Office Of Science
OSTI Identifier:
980510
Report Number(s):
BNL-93428-2010-JA
Journal ID: ISSN 1072-8368; TRN: US201015%%1895
DOE Contract Number:  
DE-AC02-98CH10886
Resource Type:
Journal Article
Journal Name:
Nature Structural and Molecular Biology
Additional Journal Information:
Journal Volume: 16; Journal ID: ISSN 1072-8368
Country of Publication:
United States
Language:
English
Subject:
36 MATERIALS SCIENCE; CRYSTAL STRUCTURE; DNA; DNA POLYMERASES; MUTATIONS; NUCLEOTIDES; RESOLUTION; SYNTHESIS; YEASTS; national synchrotron light source

Citation Formats

Swan, M, Johnson, R, Prakash, L, Prakash, S, and Aggarwal, A. Structural Basis of High-Fidelity DNA Synthesis by Yeast DNA Polymerase δ. United States: N. p., 2009. Web.
Swan, M, Johnson, R, Prakash, L, Prakash, S, & Aggarwal, A. Structural Basis of High-Fidelity DNA Synthesis by Yeast DNA Polymerase δ. United States.
Swan, M, Johnson, R, Prakash, L, Prakash, S, and Aggarwal, A. 2009. "Structural Basis of High-Fidelity DNA Synthesis by Yeast DNA Polymerase δ". United States.
@article{osti_980510,
title = {Structural Basis of High-Fidelity DNA Synthesis by Yeast DNA Polymerase δ},
author = {Swan, M and Johnson, R and Prakash, L and Prakash, S and Aggarwal, A},
abstractNote = {DNA polymerase ? (Pol ?) has a crucial role in eukaryotic replication. Now the crystal structure of the yeast DNA Pol ? catalytic subunit in complex with template primer and incoming nucleotide is presented at 2.0-A resolution, providing insight into its high fidelity and a framework to understand the effects of mutations involved in tumorigenesis.},
doi = {},
url = {https://www.osti.gov/biblio/980510}, journal = {Nature Structural and Molecular Biology},
issn = {1072-8368},
number = ,
volume = 16,
place = {United States},
year = {Thu Jan 01 00:00:00 EST 2009},
month = {Thu Jan 01 00:00:00 EST 2009}
}