Structural Basis of High-Fidelity DNA Synthesis by Yeast DNA Polymerase δ
Abstract
DNA polymerase ? (Pol ?) has a crucial role in eukaryotic replication. Now the crystal structure of the yeast DNA Pol ? catalytic subunit in complex with template primer and incoming nucleotide is presented at 2.0-A resolution, providing insight into its high fidelity and a framework to understand the effects of mutations involved in tumorigenesis.
- Authors:
- Publication Date:
- Research Org.:
- Brookhaven National Lab. (BNL), Upton, NY (United States). National Synchrotron Light Source
- Sponsoring Org.:
- Doe - Office Of Science
- OSTI Identifier:
- 980510
- Report Number(s):
- BNL-93428-2010-JA
Journal ID: ISSN 1072-8368; TRN: US201015%%1895
- DOE Contract Number:
- DE-AC02-98CH10886
- Resource Type:
- Journal Article
- Journal Name:
- Nature Structural and Molecular Biology
- Additional Journal Information:
- Journal Volume: 16; Journal ID: ISSN 1072-8368
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 36 MATERIALS SCIENCE; CRYSTAL STRUCTURE; DNA; DNA POLYMERASES; MUTATIONS; NUCLEOTIDES; RESOLUTION; SYNTHESIS; YEASTS; national synchrotron light source
Citation Formats
Swan, M, Johnson, R, Prakash, L, Prakash, S, and Aggarwal, A. Structural Basis of High-Fidelity DNA Synthesis by Yeast DNA Polymerase δ. United States: N. p., 2009.
Web.
Swan, M, Johnson, R, Prakash, L, Prakash, S, & Aggarwal, A. Structural Basis of High-Fidelity DNA Synthesis by Yeast DNA Polymerase δ. United States.
Swan, M, Johnson, R, Prakash, L, Prakash, S, and Aggarwal, A. 2009.
"Structural Basis of High-Fidelity DNA Synthesis by Yeast DNA Polymerase δ". United States.
@article{osti_980510,
title = {Structural Basis of High-Fidelity DNA Synthesis by Yeast DNA Polymerase δ},
author = {Swan, M and Johnson, R and Prakash, L and Prakash, S and Aggarwal, A},
abstractNote = {DNA polymerase ? (Pol ?) has a crucial role in eukaryotic replication. Now the crystal structure of the yeast DNA Pol ? catalytic subunit in complex with template primer and incoming nucleotide is presented at 2.0-A resolution, providing insight into its high fidelity and a framework to understand the effects of mutations involved in tumorigenesis.},
doi = {},
url = {https://www.osti.gov/biblio/980510},
journal = {Nature Structural and Molecular Biology},
issn = {1072-8368},
number = ,
volume = 16,
place = {United States},
year = {Thu Jan 01 00:00:00 EST 2009},
month = {Thu Jan 01 00:00:00 EST 2009}
}
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