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Title: DE-FG02-05ER64001 Overcoming the hurdles of multi-step targeting (MST) for effective radioimmunotherapy of solid tumors

Abstract

The 4 specific aims of this project are: (1) Optimization of MST to increase tumor uptake; (2) Antigen heterogeneity; (3) Characterization and reduction of renal uptake; and (4) Validation in vivo of optimized MST targeted therapy. This proposal focussed upon optimizing multistep immune targeting strategies for the treatment of cancer. Two multi-step targeting constructs were explored during this funding period: (1) anti-Tag-72 and (2) anti-GD2.

Authors:
; ; ;
Publication Date:
Research Org.:
Sloan-Kettering Institute for Cancer Research
Sponsoring Org.:
Office of Acquisition and Assistance
OSTI Identifier:
964281
Report Number(s):
DOE/ER/64001
TRN: US1002339
DOE Contract Number:  
FG02-05ER64001
Resource Type:
Technical Report
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; ANTIGENS; IN VIVO; NEOPLASMS; OPTIMIZATION; RADIOIMMUNOTHERAPY; THERAPY; VALIDATION

Citation Formats

I., P., Larson MD, Steven M., Co, P. I., and Nai-Kong Cheung MD, Ph. D. DE-FG02-05ER64001 Overcoming the hurdles of multi-step targeting (MST) for effective radioimmunotherapy of solid tumors. United States: N. p., 2009. Web. doi:10.2172/964281.
I., P., Larson MD, Steven M., Co, P. I., & Nai-Kong Cheung MD, Ph. D. DE-FG02-05ER64001 Overcoming the hurdles of multi-step targeting (MST) for effective radioimmunotherapy of solid tumors. United States. https://doi.org/10.2172/964281
I., P., Larson MD, Steven M., Co, P. I., and Nai-Kong Cheung MD, Ph. D. 2009. "DE-FG02-05ER64001 Overcoming the hurdles of multi-step targeting (MST) for effective radioimmunotherapy of solid tumors". United States. https://doi.org/10.2172/964281. https://www.osti.gov/servlets/purl/964281.
@article{osti_964281,
title = {DE-FG02-05ER64001 Overcoming the hurdles of multi-step targeting (MST) for effective radioimmunotherapy of solid tumors},
author = {I., P. and Larson MD, Steven M. and Co, P. I. and Nai-Kong Cheung MD, Ph. D.},
abstractNote = {The 4 specific aims of this project are: (1) Optimization of MST to increase tumor uptake; (2) Antigen heterogeneity; (3) Characterization and reduction of renal uptake; and (4) Validation in vivo of optimized MST targeted therapy. This proposal focussed upon optimizing multistep immune targeting strategies for the treatment of cancer. Two multi-step targeting constructs were explored during this funding period: (1) anti-Tag-72 and (2) anti-GD2.},
doi = {10.2172/964281},
url = {https://www.osti.gov/biblio/964281}, journal = {},
number = ,
volume = ,
place = {United States},
year = {Mon Sep 21 00:00:00 EDT 2009},
month = {Mon Sep 21 00:00:00 EDT 2009}
}