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Title: Protein detection system

The present embodiment describes a miniature, microfluidic, absorption-based sensor to detect proteins at sensitivities comparable to LIF but without the need for tagging. This instrument utilizes fiber-based evanescent-field cavity-ringdown spectroscopy, in combination with faceted prism microchannels. The combination of these techniques will increase the effective absorption path length by a factor of 10.sup.3 to 10.sup.4 (to .about.1-m), thereby providing unprecedented sensitivity using direct absorption. The coupling of high-sensitivity absorption with high-performance microfluidic separation will enable real-time sensing of biological agents in aqueous samples (including aerosol collector fluids) and will provide a general method with spectral fingerprint capability for detecting specific bio-agents.
Authors:
 [1] ;  [2] ;  [3] ;  [1]
  1. Livermore, CA
  2. Bethesda, MD
  3. San Ramon, CA
Publication Date:
OSTI Identifier:
963807
Report Number(s):
7,527,977
US patent application 11/087,942
DOE Contract Number:
AC04-94AL85000
Resource Type:
Patent
Research Org:
Sandia National Laboratories (SNL-CA), Livermore, CA
Sponsoring Org:
United States Department of Energy
Country of Publication:
United States
Language:
English
Subject:
47 OTHER INSTRUMENTATION