skip to main content

Title: Unbalanced 5;16 translocation in a boy with papillary thyroid carcinoma

This is the first reported case of an unbalanced chromosome rearrangement resulting in trisomy 5q35.5{r_arrow}qter and monosomy 16p 13.3{r_arrow}pter, in a boy with mental and growth retardation, minor anomalies, and a history of bilateral papillary thyroid carcinoma. This was the result of a familial balanced translocation. The clinical and cytogenetic manifestations of the case are presented and the possible role of the chromosomal rearrangement in the etiology of the thyroid carcinoma is discussed. 25 refs., 5 figs., 1 tab.
Authors:
; ; ;  [1]
  1. Univ. of Michigan, Ann Arbor, MI (United States)
Publication Date:
OSTI Identifier:
96085
Resource Type:
Journal Article
Resource Relation:
Journal Name: American Journal of Medical Genetics; Journal Volume: 49; Journal Issue: 3; Other Information: PBD: 1 Feb 1994
Sponsoring Org:
USDOE
Country of Publication:
United States
Language:
English
Subject:
55 BIOLOGY AND MEDICINE, BASIC STUDIES; THYROID; CARCINOMAS; ETIOLOGY; HUMAN CHROMOSOME 5; CHROMOSOMAL ABERRATIONS; HUMAN CHROMOSOME 16; ANEUPLOIDY; MENTAL DISORDERS