Linkage localization of the thoraco-abdominal syndrome (TAS) gene to Xq25-26
Journal Article
·
· American Journal of Medical Genetics
- Univ. of the Negev, Beer-Sheva (Israel)
- Tel-Aviv Univ., Tel-Aviv (Israel)
- Univ. Hadassa Medical School, Jerusalem (Israel)
The thoraco-abdominal syndrome (TAS) presents a closure defect confined to the ventral midline, manifested as ventral hernia of various degrees in all affected individuals and antero-lateral diaphragmatic defect manifested almost exclusively in affected males. The syndrome is inherited as an X-linked dominant trait affecting blastogenesis (XLB mutation). The authors studied 27 members of the TAS family for linkage on the X chromosome. The best lod score of 5.5 at {theta}0.04 was found for the HPRT locus on Xq26.1. A multilocus lod score of 12.4 was observed when the linkage analysis utilized additional markers in Xq25-26. 28 refs., 2 figs., 1 tab.
- Sponsoring Organization:
- USDOE
- OSTI ID:
- 95930
- Journal Information:
- American Journal of Medical Genetics, Vol. 49, Issue 4; Other Information: PBD: 15 Feb 1994
- Country of Publication:
- United States
- Language:
- English
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