Optimization of nanoparticle core size for magnetic particle imaging
Magnetic Particle Imaging (MPI) is a powerful new diagnostic visualization platform designed for measuring the amount and location of superparamagnetic nanoscale molecular probes (NMPs) in biological tissues. Promising initial results indicate that MPI can be extremely sensitive and fast, with good spatial resolution for imaging human patients or live animals. Here, we present modeling results that show how MPI sensitivity and spatial resolution both depend on NMP-core physical properties, and how MPI performance can be effectively optimized through rational core design. Monodisperse magnetite cores are attractive since they are readily produced with a biocompatible coating and controllable size that facilitates quantitative imaging.
- Research Organization:
- Pacific Northwest National Lab. (PNNL), Richland, WA (United States). Environmental Molecular Sciences Lab. (EMSL)
- Sponsoring Organization:
- USDOE
- DOE Contract Number:
- AC05-76RL01830
- OSTI ID:
- 956894
- Report Number(s):
- PNNL-SA-61021; 25691; 400412000
- Journal Information:
- Journal of Magnetism and Magnetic Materials, 321(10):1548-1551, Journal Name: Journal of Magnetism and Magnetic Materials, 321(10):1548-1551
- Country of Publication:
- United States
- Language:
- English
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