Dynamics Modelling of Biolistic Gene Guns
Abstract
The gene transfer process using biolistic gene guns is a highly dynamic process. To achieve good performance, the process needs to be well understood and controlled. Unfortunately, no dynamic model is available in the open literature for analysing and controlling the process. This paper proposes such a model. Relationships of the penetration depth with the helium pressure, the penetration depth with the acceleration distance, and the penetration depth with the micro-carrier radius are presented. Simulations have also been conducted. The results agree well with experimental results in the open literature. The contribution of this paper includes a dynamic model for improving and manipulating performance of the biolistic gene gun.
- Authors:
- Publication Date:
- Research Org.:
- SLAC National Accelerator Lab., Menlo Park, CA (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 953912
- Report Number(s):
- SLAC-REPRINT-2009-480
Journal ID: ISSN 0031-9155; PHMBA7; TRN: US201004%%649
- DOE Contract Number:
- AC02-76SF00515
- Resource Type:
- Journal Article
- Journal Name:
- Phys. Med. Biol. 52:1485,2007
- Additional Journal Information:
- Journal Volume: 52; Journal ID: ISSN 0031-9155
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES; 99 GENERAL AND MISCELLANEOUS//MATHEMATICS, COMPUTING, AND INFORMATION SCIENCE; ACCELERATION; DISTANCE; DYNAMICS; GENES; GUNS; HELIUM; PENETRATION DEPTH; PERFORMANCE; SIMULATION; Other,OTHER, BIO
Citation Formats
Zhang, M, Tao, W, and Pianetta, P A. Dynamics Modelling of Biolistic Gene Guns. United States: N. p., 2009.
Web.
Zhang, M, Tao, W, & Pianetta, P A. Dynamics Modelling of Biolistic Gene Guns. United States.
Zhang, M, Tao, W, and Pianetta, P A. 2009.
"Dynamics Modelling of Biolistic Gene Guns". United States.
@article{osti_953912,
title = {Dynamics Modelling of Biolistic Gene Guns},
author = {Zhang, M and Tao, W and Pianetta, P A},
abstractNote = {The gene transfer process using biolistic gene guns is a highly dynamic process. To achieve good performance, the process needs to be well understood and controlled. Unfortunately, no dynamic model is available in the open literature for analysing and controlling the process. This paper proposes such a model. Relationships of the penetration depth with the helium pressure, the penetration depth with the acceleration distance, and the penetration depth with the micro-carrier radius are presented. Simulations have also been conducted. The results agree well with experimental results in the open literature. The contribution of this paper includes a dynamic model for improving and manipulating performance of the biolistic gene gun.},
doi = {},
url = {https://www.osti.gov/biblio/953912},
journal = {Phys. Med. Biol. 52:1485,2007},
issn = {0031-9155},
number = ,
volume = 52,
place = {United States},
year = {Thu Jun 04 00:00:00 EDT 2009},
month = {Thu Jun 04 00:00:00 EDT 2009}
}