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Title: Dynamics Modelling of Biolistic Gene Guns

Abstract

The gene transfer process using biolistic gene guns is a highly dynamic process. To achieve good performance, the process needs to be well understood and controlled. Unfortunately, no dynamic model is available in the open literature for analysing and controlling the process. This paper proposes such a model. Relationships of the penetration depth with the helium pressure, the penetration depth with the acceleration distance, and the penetration depth with the micro-carrier radius are presented. Simulations have also been conducted. The results agree well with experimental results in the open literature. The contribution of this paper includes a dynamic model for improving and manipulating performance of the biolistic gene gun.

Authors:
; ;
Publication Date:
Research Org.:
SLAC National Accelerator Lab., Menlo Park, CA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
953912
Report Number(s):
SLAC-REPRINT-2009-480
Journal ID: ISSN 0031-9155; PHMBA7; TRN: US201004%%649
DOE Contract Number:  
AC02-76SF00515
Resource Type:
Journal Article
Journal Name:
Phys. Med. Biol. 52:1485,2007
Additional Journal Information:
Journal Volume: 52; Journal ID: ISSN 0031-9155
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; 99 GENERAL AND MISCELLANEOUS//MATHEMATICS, COMPUTING, AND INFORMATION SCIENCE; ACCELERATION; DISTANCE; DYNAMICS; GENES; GUNS; HELIUM; PENETRATION DEPTH; PERFORMANCE; SIMULATION; Other,OTHER, BIO

Citation Formats

Zhang, M, Tao, W, and Pianetta, P A. Dynamics Modelling of Biolistic Gene Guns. United States: N. p., 2009. Web.
Zhang, M, Tao, W, & Pianetta, P A. Dynamics Modelling of Biolistic Gene Guns. United States.
Zhang, M, Tao, W, and Pianetta, P A. 2009. "Dynamics Modelling of Biolistic Gene Guns". United States.
@article{osti_953912,
title = {Dynamics Modelling of Biolistic Gene Guns},
author = {Zhang, M and Tao, W and Pianetta, P A},
abstractNote = {The gene transfer process using biolistic gene guns is a highly dynamic process. To achieve good performance, the process needs to be well understood and controlled. Unfortunately, no dynamic model is available in the open literature for analysing and controlling the process. This paper proposes such a model. Relationships of the penetration depth with the helium pressure, the penetration depth with the acceleration distance, and the penetration depth with the micro-carrier radius are presented. Simulations have also been conducted. The results agree well with experimental results in the open literature. The contribution of this paper includes a dynamic model for improving and manipulating performance of the biolistic gene gun.},
doi = {},
url = {https://www.osti.gov/biblio/953912}, journal = {Phys. Med. Biol. 52:1485,2007},
issn = {0031-9155},
number = ,
volume = 52,
place = {United States},
year = {Thu Jun 04 00:00:00 EDT 2009},
month = {Thu Jun 04 00:00:00 EDT 2009}
}