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Title: Post-Treatment Hemodynamics of a Basilar Aneurysm and Bifurcation

Aneurysm re-growth and rupture can sometimes unexpectedly occur following treatment procedures that were initially considered to be successful at the time of treatment and post-operative angiography. In some cases, this can be attributed to surgical clip slippage or endovascular coil compaction. However, there are other cases in which the treatment devices function properly. In these instances, the subsequent complications are due to other factors, perhaps one of which is the post-treatment hemodynamic stress. To investigate whether or not a treatment procedure can subject the parent artery to harmful hemodynamic stresses, computational fluid dynamics simulations are performed on a patient-specific basilar aneurysm and bifurcation before and after a virtual endovascular treatment. The simulations demonstrate that the treatment procedure produces a substantial increase in the wall shear stress. Analysis of the post-treatment flow field indicates that the increase in wall shear stress is due to the impingement of the basilar artery flow upon the aneurysm filling material and to the close proximity of a vortex tube to the artery wall. Calculation of the time-averaged wall shear stress shows that there is a region of the artery exposed to a level of wall shear stress that can cause severe damage to endothelial cells.more » The results of this study demonstrate that it is possible for a treatment procedure, which successfully excludes the aneurysm from the vascular system and leaves no aneurysm neck remnant, to elevate the hemodynamic stresses to levels that are injurious to the immediately adjacent vessel wall.« less
Authors:
; ; ;
Publication Date:
OSTI Identifier:
944311
Report Number(s):
LLNL-JRNL-400737
Journal ID: ISSN 0090-6964; ABMECF; TRN: US200902%%673
DOE Contract Number:
W-7405-ENG-48
Resource Type:
Journal Article
Resource Relation:
Journal Name: Annals of Biomedical Engineering, vol. 36, no. 9, July 16, 2008, pp. 1531-1546; Journal Volume: 36; Journal Issue: 9
Research Org:
Lawrence Livermore National Laboratory (LLNL), Livermore, CA
Sponsoring Org:
USDOE
Country of Publication:
United States
Language:
English
Subject:
42 ENGINEERING; 59 BASIC BIOLOGICAL SCIENCES; BIFURCATION; BIOMEDICAL RADIOGRAPHY; BLOOD VESSELS; COMPUTERIZED SIMULATION; FLUID MECHANICS; IMPINGEMENT; RUPTURES; SHEAR; STRESSES