Post-Treatment Hemodynamics of a Basilar Aneurysm and Bifurcation

Ortega, J; Hartman, J; Rodriguez, J; Maitland, D

doi:10.1007/s10439-008-9535-7

Title: Post-Treatment Hemodynamics of a Basilar Aneurysm and Bifurcation

Journal Article · Wed Jan 16 00:00:00 EST 2008 · Annals of Biomedical Engineering

DOI:https://doi.org/10.1007/s10439-008-9535-7· OSTI ID:944311

Ortega, J; Hartman, J; Rodriguez, J; Maitland, D

Aneurysm re-growth and rupture can sometimes unexpectedly occur following treatment procedures that were initially considered to be successful at the time of treatment and post-operative angiography. In some cases, this can be attributed to surgical clip slippage or endovascular coil compaction. However, there are other cases in which the treatment devices function properly. In these instances, the subsequent complications are due to other factors, perhaps one of which is the post-treatment hemodynamic stress. To investigate whether or not a treatment procedure can subject the parent artery to harmful hemodynamic stresses, computational fluid dynamics simulations are performed on a patient-specific basilar aneurysm and bifurcation before and after a virtual endovascular treatment. The simulations demonstrate that the treatment procedure produces a substantial increase in the wall shear stress. Analysis of the post-treatment flow field indicates that the increase in wall shear stress is due to the impingement of the basilar artery flow upon the aneurysm filling material and to the close proximity of a vortex tube to the artery wall. Calculation of the time-averaged wall shear stress shows that there is a region of the artery exposed to a level of wall shear stress that can cause severe damage to endothelial cells. The results of this study demonstrate that it is possible for a treatment procedure, which successfully excludes the aneurysm from the vascular system and leaves no aneurysm neck remnant, to elevate the hemodynamic stresses to levels that are injurious to the immediately adjacent vessel wall.

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Research Organization:: Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States)

Sponsoring Organization:: USDOE

DOE Contract Number:: W-7405-ENG-48

OSTI ID:: 944311

Report Number(s):: LLNL-JRNL-400737; ABMECF; TRN: US200902%%673

Journal Information:: Annals of Biomedical Engineering, Vol. 36, Issue 9; ISSN 0090-6964

Country of Publication:: United States

Language:: English

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Title: Post-Treatment Hemodynamics of a Basilar Aneurysm and Bifurcation

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