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Title: Application of Proteomics and Lipid Studies in Environmental Biotechnology

The overview of changes in protein levels or states in response to a growth condition, stress, mutation or metabolic engineering is invaluable in understanding the physiology of a microbial system. The lipid profile of the cell is similarly a valuable diagnostic of the cellular response and health, especially in context of survival in a fluctuating environment. To obtain comprehensive cellular models, post-transcriptional cell wide surveys at the levels of proteins and lipids are required. Both these fields have been greatly bolstered by the development of high throughput methods using mass spectrometry. Multiple strategies now exist for the identification of proteins, and numerous workflows to quantify protein abundance have also been developed. Cellular profiling such as these allows us to assess the potential of a microbial system for environmental applications such as bioremediation and bio-energy.
Authors:
Publication Date:
OSTI Identifier:
937573
Report Number(s):
LBNL-943E
TRN: US200819%%260
DOE Contract Number:
DE-AC02-05CH11231
Resource Type:
Conference
Resource Relation:
Conference: Society for Industrial Microbiology 2008 Annual Meeting, San Diego, CA, 08/10-14/2008
Research Org:
Ernest Orlando Lawrence Berkeley National Laboratory, Berkeley, CA (US)
Sponsoring Org:
Physical Biosciences Division
Country of Publication:
United States
Language:
English
Subject:
09; 59; 54; ABUNDANCE; BIOREMEDIATION; BIOTECHNOLOGY; LIPIDS; MASS SPECTROSCOPY; MUTATIONS; PHYSIOLOGY; PROTEINS Bioremediation, Functional Genomics, Lipidomics, Proteomics