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Title: Investigation of Water-Soluble X-ray Luminescence Nanoparticles for Photodynamic Activation

Abstract

In this letter, we report the synthesis of LaF3:Tb3+-MTCP (meso-Tetra(4-carboxyphenyl) porphine) nanoparticle conjugates and investigate the energy transfer as well as singlet oxygen generation following X-ray irradiation. Our observations indicate that LaF3:Tb3+-MTCP nanoparticle conjugates are efficient photodynamic agents that can be initiated by X-rays at a reasonably low dose. The addition of folic acid to facilitate targeting to folate receptors on tumor cells has no effect on the quantum yield of singlet oxygen in the nanoparticle-MTCP conjugates. Our pilot studies indicate that water-soluble scintillation nanoparticles can be potentially used to activate photodynamic therapy as a promising deep cancer treatment.

Authors:
; ; ;
Publication Date:
Research Org.:
Pacific Northwest National Lab. (PNNL), Richland, WA (United States). Environmental Molecular Sciences Lab. (EMSL)
Sponsoring Org.:
USDOE
OSTI Identifier:
925475
Report Number(s):
PNNL-SA-58245
Journal ID: ISSN 0003-6951; APPLAB; 24804; KP1504020; TRN: US200809%%500
DOE Contract Number:  
AC05-76RL01830
Resource Type:
Journal Article
Journal Name:
Applied Physics Letters, 92(4):Art. No. 043901
Additional Journal Information:
Journal Volume: 92; Journal Issue: 4; Journal ID: ISSN 0003-6951
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; LANTHANUM FLUORIDES; TERBIUM COMPOUNDS; PORPHYRINS; SYNTHESIS; NANOSTRUCTURES; ENERGY TRANSFER; IRRADIATION; X RADIATION; LUMINESCENCE; NEOPLASMS; SCINTILLATIONS; THERAPY; TUMOR CELLS; Environmental Molecular Sciences Laboratory

Citation Formats

Liu, Yuanfang, Chen, Wei, Wang, Shaopeng, and Joly, Alan G. Investigation of Water-Soluble X-ray Luminescence Nanoparticles for Photodynamic Activation. United States: N. p., 2008. Web. doi:10.1063/1.2835701.
Liu, Yuanfang, Chen, Wei, Wang, Shaopeng, & Joly, Alan G. Investigation of Water-Soluble X-ray Luminescence Nanoparticles for Photodynamic Activation. United States. https://doi.org/10.1063/1.2835701
Liu, Yuanfang, Chen, Wei, Wang, Shaopeng, and Joly, Alan G. 2008. "Investigation of Water-Soluble X-ray Luminescence Nanoparticles for Photodynamic Activation". United States. https://doi.org/10.1063/1.2835701.
@article{osti_925475,
title = {Investigation of Water-Soluble X-ray Luminescence Nanoparticles for Photodynamic Activation},
author = {Liu, Yuanfang and Chen, Wei and Wang, Shaopeng and Joly, Alan G},
abstractNote = {In this letter, we report the synthesis of LaF3:Tb3+-MTCP (meso-Tetra(4-carboxyphenyl) porphine) nanoparticle conjugates and investigate the energy transfer as well as singlet oxygen generation following X-ray irradiation. Our observations indicate that LaF3:Tb3+-MTCP nanoparticle conjugates are efficient photodynamic agents that can be initiated by X-rays at a reasonably low dose. The addition of folic acid to facilitate targeting to folate receptors on tumor cells has no effect on the quantum yield of singlet oxygen in the nanoparticle-MTCP conjugates. Our pilot studies indicate that water-soluble scintillation nanoparticles can be potentially used to activate photodynamic therapy as a promising deep cancer treatment.},
doi = {10.1063/1.2835701},
url = {https://www.osti.gov/biblio/925475}, journal = {Applied Physics Letters, 92(4):Art. No. 043901},
issn = {0003-6951},
number = 4,
volume = 92,
place = {United States},
year = {Mon Jan 28 00:00:00 EST 2008},
month = {Mon Jan 28 00:00:00 EST 2008}
}