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Title: Synthetic Nano-Low Density Lipoprotein as Targeted Drug DeliveryVehicle for Glioblastoma Multiforme

This paper discribes a synthetic low density lipoprotein(LDL) made by complexing a 29 amino acid that consists of a lipid bindingdomain and the LDL receptor binding domain with a lipid microemulsion.The nano-LDL particles were intermdiate in size between LDL and HDL andbound to LDL receptors on GBM brain tumor cells. Synthetic nano-LDLuptake by GBM cells was LDL receptor specific and dependent on cellreceptor number. It is suggested that these synthetic particles can serveas a delivery vehicle for hydophobic anti-tumor drugs by targeting theLDL receptor.
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Publication Date:
OSTI Identifier:
Report Number(s):
Journal ID: ISSN 0378-5173; IJPHDE; R&D Project: 440Z01; BnR: KP1102020; TRN: US200804%%834
DOE Contract Number:
Resource Type:
Journal Article
Resource Relation:
Journal Name: International Journal of Pharmaceutics; Journal Volume: 328; Journal Issue: 1; Related Information: Journal Publication Date: 07/31/2006
Research Org:
Ernest Orlando Lawrence Berkeley NationalLaboratory, Berkeley, CA (US)
Sponsoring Org:
USDOE Director. Office of Science. Biological andEnvironmental Research
Country of Publication:
United States
60; 60; AMINO ACIDS; BRAIN; GLIOMAS; LIPIDS; LIPOPROTEINS; TUMOR CELLS LDL receptor microemulsion synthetic nano-LDL