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Title: Recombinant constructs of Borrelia burgdorferi

Novel chimeric nucleic acids, encoding chimeric Borrelia proteins comprising OspC or an antigenic fragment thereof and OspA or an antigenic fragment thereof, are disclosed. Chimeric proteins encoded by the nucleic acid sequences are also disclosed. The chimeric proteins are useful as vaccine immunogens against Lyme borreliosis, as well as for immunodiagnostic reagents.
Authors:
 [1] ;  [2] ;  [3] ;  [4]
  1. (Setauket, NY)
  2. (New York, NY)
  3. (East Setauket, NY)
  4. (Bellport, NY)
Publication Date:
OSTI Identifier:
919842
Report Number(s):
7,179,448
Resource Type:
Patent
Research Org:
Brookhaven National Laboratory (BNL), Upton, NY
Sponsoring Org:
USDOE - Office of Science (SC)
Country of Publication:
United States
Language:
English