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Title: Directed evolution methods for improving polypeptide folding and solubility and superfolder fluorescent proteins generated thereby

The current invention provides methods of improving folding of polypeptides using a poorly folding domain as a component of a fusion protein comprising the poorly folding domain and a polypeptide of interest to be improved. The invention also provides novel green fluorescent proteins (GFPs) and red fluorescent proteins that have enhanced folding properties.
Authors:
 [1]
  1. (Santa Fe, NM)
Publication Date:
OSTI Identifier:
915234
Report Number(s):
7,271,241
US patent application 10/423,688
DOE Contract Number:
W-7405-ENG-36
Resource Type:
Patent
Research Org:
Los Alamos National Laboratory (LANL), Los Alamos, NM
Sponsoring Org:
United States Department of Energy
Country of Publication:
United States
Language:
English