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Title: Ion mobility analysis of lipoproteins

A medical diagnostic method and instrumentation system for analyzing noncovalently bonded agglomerated biological particles is described. The method and system comprises: a method of preparation for the biological particles; an electrospray generator; an alpha particle radiation source; a differential mobility analyzer; a particle counter; and data acquisition and analysis means. The medical device is useful for the assessment of human diseases, such as cardiac disease risk and hyperlipidemia, by rapid quantitative analysis of lipoprotein fraction densities. Initially, purification procedures are described to reduce an initial blood sample to an analytical input to the instrument. The measured sizes from the analytical sample are correlated with densities, resulting in a spectrum of lipoprotein densities. The lipoprotein density distribution can then be used to characterize cardiac and other lipid-related health risks.
Authors:
 [1] ;  [2] ;  [2]
  1. (Danville, CA)
  2. (Berkeley, CA)
Publication Date:
OSTI Identifier:
913426
Report Number(s):
7,259,018
US patent application 10/293,610
DOE Contract Number:
AC03-76SF00098
Resource Type:
Patent
Research Org:
Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA
Sponsoring Org:
United States Department of Energy
Country of Publication:
United States
Language:
English