Linkage analysis between manic-depressive illness and 35 classical markers

Journal Article · Wed Jun 15 00:00:00 EDT 1994 · American Journal of Medical Genetics

DOI:https://doi.org/10.1002/ajmg.1320540210· OSTI ID:91094

Ewald, H; Mors, O; Eiberg, H ^[1]

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1. Univ. Institute of Medical Genetics, Copenhagen (Denmark)

The present study used carefully established phenotypes, several methods to reduce misclassification, and conservative genetic parameters. For the 35 markers investigated no evidence of linkage to manic-depressive illness was found, especially not to the markers on chromosomes 4q, 9q, and 19, which earlier has been suggested as possibly being linked to subtypes of manic-depressive illness. Close linkage to FY and SS(GYPB) was excluded for all chosen phenotypic models and to ACP1 and ADA for broader phenotypic models. 25 refs., 1 fig., 1 tab.

• Sponsoring Organization: USDOE
• OSTI ID: 91094
• Journal Information: American Journal of Medical Genetics, Vol. 54, Issue 2; Other Information: PBD: 15 Jun 1994
• Country of Publication: United States
• Language: English

Related Subjects

55 BIOLOGY AND MEDICINE
BASIC STUDIES
PATIENTS
MENTAL DISORDERS
PHENOTYPE
HUMAN CHROMOSOMES
GENETIC MAPPING
STATISTICAL MODELS
GENETICS
GENES
BIOLOGICAL MARKERS
HUMAN CHROMOSOME 9
HUMAN CHROMOSOME 19