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Title: Velo-cardio-facial syndrome and psychotic disorders: Implications for psychiatric genetics

Psychiatric disorders have been reported in over 10% of patients with velo-cardio-facial syndrome (VCFS) in long-term follow-up. To further explore the behavioral and psychiatric findings associated with VCFS in adulthood, detailed clinical histories of two patients - one with VCFS who developed a psychotic illness, and one with schizophrenia who was found to have dysmorphological features associated with VCFS - are described in the current report. The observed overlap of physical and psychiatric symptoms in these two patients suggests that VCFS and psychotic disorders may share a pathogenetic mechanism. This could be consistent with a contiguous gene model for VCFS and psychosis, suggesting chromosome 22q11 as a possible candidate region for genetic studies of schizophrenia. 26 refs., 2 tabs.
Authors:
; ;  [1]
  1. Univ. of Toronto, Ontario (Canada)
Publication Date:
OSTI Identifier:
91091
Resource Type:
Journal Article
Resource Relation:
Journal Name: American Journal of Medical Genetics; Journal Volume: 54; Journal Issue: 2; Other Information: PBD: 15 Jun 1994
Sponsoring Org:
USDOE
Country of Publication:
United States
Language:
English
Subject:
55 BIOLOGY AND MEDICINE, BASIC STUDIES; PATIENTS; MENTAL DISORDERS; NERVOUS SYSTEM DISEASES; HUMAN CHROMOSOME 22; GENETIC MAPPING; DNA HYBRIDIZATION; FLUORESCENCE