Progress in a genome scan for linkage in schizophrenia in a large Swedish kindred
- Yale Univ. School of Medicine, New Haven, CT (United States); and others
Genetic linkage studies of a kindred from Sweden segregating for schizophrenia have been performed using a genetic model (autosomal dominant, f - 0.72, q - 0.02, phenocopies=0.001) as described in Kennedy et al., 1988. Analyses of the restriction fragment length polymorphism (RFLP), allele-specific oligonucleotides (ASO), and short tandem repeat (STR also called microsatellite) data for 180 polymorphisms (individual probe-enzyme, ASO, or STR systems) at 155 loci have been completed using the MLINK and LIPED programs. Linkage to schizophrenia was excluded, under the given model, at 47 loci; indeterminate lod scores occurred at 108 loci. The total exclusion region across 20 chromosomes is estimated at 330 cM; 211 cM excluded by pairwise analyses and 119 cM previously excluded by multipoint analyses. 37 refs., 2 tabs.
- Sponsoring Organization:
- USDOE
- OSTI ID:
- 91063
- Journal Information:
- American Journal of Medical Genetics, Vol. 54, Issue 1; Other Information: PBD: 15 Mar 1994
- Country of Publication:
- United States
- Language:
- English
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