skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Hematopoietic stem cell compartment: Acute and late effects of radiation therapy an chemotherapy

Abstract

The bone marrow is an important dose-limiting cell renewal tissue for chemotherapy, wide-field irradiation, and autologous bone marrow transplantion. Over the past 5-10 years a great deal has been discovered about the hematopoietic stem cell compartment. Although the toxicity associated with prolonged myelosuppression continue to limit the wider use of chemotherapy and irradiation, ways are being discovered to circumvent this toxicity such as with the increasing use of cytokines. This review describes what is known of how chemotherapy and irradiation damage stem cells and the microenvironment, how cytokines protect hematopoietic cells from radiation damage and speed marrow recovery after chemotherapy or marrow transplantation, and how various types of blood marrow cells contribute to engraftment and long-term hematopoiesis after high doses of cytotoxic agents and/or total body irradiation. 167 refs., 7 figs., 6 tabs.

Authors:
 [1];  [2];  [3]
  1. Harvard Medical School, Boston, MA (United States)
  2. Univ. of Rochester Medical School, NY (United States)
  3. Univ. of Pittsburgh Medical Center, PA (United States); and others
Publication Date:
OSTI Identifier:
90892
Resource Type:
Journal Article
Journal Name:
International Journal of Radiation Oncology, Biology and Physics
Additional Journal Information:
Journal Volume: 31; Journal Issue: 5; Other Information: PBD: 30 Mar 1995
Country of Publication:
United States
Language:
English
Subject:
55 BIOLOGY AND MEDICINE, BASIC STUDIES; 56 BIOLOGY AND MEDICINE, APPLIED STUDIES; BONE MARROW; CHEMOTHERAPY; RADIOTHERAPY; STEM CELLS; RADIATION INJURIES; DELAYED RADIATION EFFECTS; BLOOD; TOXICITY; HEMATOPOIETIC SYSTEM

Citation Formats

Mauch, P, Constine, L, and Greenberger, J. Hematopoietic stem cell compartment: Acute and late effects of radiation therapy an chemotherapy. United States: N. p., 1995. Web. doi:10.1016/0360-3016(94)00430-S.
Mauch, P, Constine, L, & Greenberger, J. Hematopoietic stem cell compartment: Acute and late effects of radiation therapy an chemotherapy. United States. https://doi.org/10.1016/0360-3016(94)00430-S
Mauch, P, Constine, L, and Greenberger, J. 1995. "Hematopoietic stem cell compartment: Acute and late effects of radiation therapy an chemotherapy". United States. https://doi.org/10.1016/0360-3016(94)00430-S.
@article{osti_90892,
title = {Hematopoietic stem cell compartment: Acute and late effects of radiation therapy an chemotherapy},
author = {Mauch, P and Constine, L and Greenberger, J},
abstractNote = {The bone marrow is an important dose-limiting cell renewal tissue for chemotherapy, wide-field irradiation, and autologous bone marrow transplantion. Over the past 5-10 years a great deal has been discovered about the hematopoietic stem cell compartment. Although the toxicity associated with prolonged myelosuppression continue to limit the wider use of chemotherapy and irradiation, ways are being discovered to circumvent this toxicity such as with the increasing use of cytokines. This review describes what is known of how chemotherapy and irradiation damage stem cells and the microenvironment, how cytokines protect hematopoietic cells from radiation damage and speed marrow recovery after chemotherapy or marrow transplantation, and how various types of blood marrow cells contribute to engraftment and long-term hematopoiesis after high doses of cytotoxic agents and/or total body irradiation. 167 refs., 7 figs., 6 tabs.},
doi = {10.1016/0360-3016(94)00430-S},
url = {https://www.osti.gov/biblio/90892}, journal = {International Journal of Radiation Oncology, Biology and Physics},
number = 5,
volume = 31,
place = {United States},
year = {Thu Mar 30 00:00:00 EST 1995},
month = {Thu Mar 30 00:00:00 EST 1995}
}