Smallest LDL particles are most strongly related to coronarydisease progression in men
Objective-LDLs include particle subclasses that havedifferent mobilities on polyacrylamide gradient gels: LDL-I (27.2to 28.5nm), LDL-IIa (26.5 to 27.2 nm), LDL-IIb (25.6 to 26.5 nm), LDL-IIIa (24.7to 25.6 nm), LDL-IIIb (24.2 to 24.7nm), LDL-IVa (23.3 to 24.2 nm), andLDL-IVb (22.0 to 23.3 nm in diameter). We hypothesized that theassociationbetween smaller LDL particles and coronary artery disease(CAD) risk might involve specific LDL subclasses.Methods andResults-Average 4-year onstudy lipoprotein measurements were comparedwith annualized rates of stenosischange from baseline to 4 years in 117men with CAD. The percentages of total LDL and HDL occurringwithinindividual subclasses were measured by gradient gelelectrophoresis. Annual rate of stenosis change was relatedconcordantlyto onstudy averages of total cholesterol (P 0.04), triglycerides (P0.05), VLDL mass (P 0.03),total/HDL cholesterol ratio (P 0.04), LDL-IVb(P 0.01), and HDL3a (P 0.02) and inversely to HDL2-mass (P 0.02)and HDL2b(P 0.03). The average annual rate in stenosis change was 6-fold morerapid in the fourth quartile ofLDL-IVb (5.2 percent) than in the firstquartile ( 2.5 percent, P 0.03). Stepwise multiple regression analysisshowed thatLDL-IVb was the single best predictor of stenosischange.Conclusions-LDL-IVb was the single best lipoprotein predictor ofincreased stenosis, an unexpected result, given thatLDL-IVb representsonly a minor fraction of total LDL. (Arterioscler Thromb Vasc Biol.2003;23:314-321.)
- Research Organization:
- Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
- Sponsoring Organization:
- USOER; National Institutes of Health. National Heart Lungand Blood Institute Grant HL-58621
- DOE Contract Number:
- DE-AC02-05CH11231
- OSTI ID:
- 903111
- Report Number(s):
- LBNL-48099; R&D Project: L0118; BnR: 400412000; TRN: US200720%%81
- Journal Information:
- Arteriosclerosis, Thrombosis, and VascularBiology, Vol. 23; Related Information: Journal Publication Date: 12/19/2002
- Country of Publication:
- United States
- Language:
- English
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