A conserved checkpoint monitors meiotic chromosome synapsis inCaenorhabditis elegans
Abstract
We report the discovery of a checkpoint that monitorssynapsis between homologous chromosomes to ensure accurate meioticsegregation. Oocytes containing unsynapsed chromosomes selectivelyundergo apoptosis even if agermline DNA damage checkpoint is inactivated.This culling mechanism isspecifically activated by unsynapsed pairingcenters, cis-acting chromosomesites that are also required to promotesynapsis in Caenorhabditis elegans. Apoptosis due to synaptic failurealso requires the C. elegans homolog of PCH2,a budding yeast pachytenecheckpoint gene, which suggests that this surveillance mechanism iswidely conserved.
- Authors:
- Publication Date:
- Research Org.:
- Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
- Sponsoring Org.:
- USDOE; National Institutes of Health Grants 1 F32GM67408-01A1 and 1 R01 GM/CA655591-01; Burroughs Wellcome Career Award1000950
- OSTI Identifier:
- 901805
- Report Number(s):
- LBNL-58820
Journal ID: ISSN 0193-4511; SCEHDK; R&D Project: 862E2B; BnR: 400412000; TRN: US200715%%143
- DOE Contract Number:
- DE-AC02-05CH11231
- Resource Type:
- Journal Article
- Journal Name:
- Science
- Additional Journal Information:
- Journal Volume: 310; Journal Issue: 5754; Related Information: Journal Publication Date: 9 December2005; Journal ID: ISSN 0193-4511
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59; APOPTOSIS; CHROMOSOMES; DNA DAMAGES; MONITORS; OOCYTES; SEGREGATION; YEASTS; Meiosis C. elegans homologous pairing chromosome synapsischeckpoints apoptosis
Citation Formats
Bhalla, Needhi, and Dernburg, Abby F. A conserved checkpoint monitors meiotic chromosome synapsis inCaenorhabditis elegans. United States: N. p., 2005.
Web.
Bhalla, Needhi, & Dernburg, Abby F. A conserved checkpoint monitors meiotic chromosome synapsis inCaenorhabditis elegans. United States.
Bhalla, Needhi, and Dernburg, Abby F. 2005.
"A conserved checkpoint monitors meiotic chromosome synapsis inCaenorhabditis elegans". United States.
@article{osti_901805,
title = {A conserved checkpoint monitors meiotic chromosome synapsis inCaenorhabditis elegans},
author = {Bhalla, Needhi and Dernburg, Abby F},
abstractNote = {We report the discovery of a checkpoint that monitorssynapsis between homologous chromosomes to ensure accurate meioticsegregation. Oocytes containing unsynapsed chromosomes selectivelyundergo apoptosis even if agermline DNA damage checkpoint is inactivated.This culling mechanism isspecifically activated by unsynapsed pairingcenters, cis-acting chromosomesites that are also required to promotesynapsis in Caenorhabditis elegans. Apoptosis due to synaptic failurealso requires the C. elegans homolog of PCH2,a budding yeast pachytenecheckpoint gene, which suggests that this surveillance mechanism iswidely conserved.},
doi = {},
url = {https://www.osti.gov/biblio/901805},
journal = {Science},
issn = {0193-4511},
number = 5754,
volume = 310,
place = {United States},
year = {Thu Jul 14 00:00:00 EDT 2005},
month = {Thu Jul 14 00:00:00 EDT 2005}
}
Other availability
Save to My Library
You must Sign In or Create an Account in order to save documents to your library.