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Title: A Very High Spatial Resolution Detector for Small Animal PET

Positron Emission Tomography (PET) is an in vivo analog of autoradiography and has the potential to become a powerful new tool in imaging biological processes in small laboratory animals. PET imaging of small animals can provide unique information that can help in advancement of human disease models as well as drug development. Clinical PET scanners used for human imaging are bulky, expensive and do not have adequate spatial resolution for small animal studies. Hence, dedicated, low cost instruments are required for conducting small animal studies with higher spatial resolution than what is currently achieved with clinical as well as dedicated small animal PET scanners. The goal of the proposed project is to investigate a new all solid-state detector design for small animal PET imaging. Exceptionally high spatial resolution, good timing resolution, and excellent energy resolution are expected from the proposed detector design. The Phase I project was aimed at demonstrating the feasibility of producing high performance solid-state detectors that provide high sensitivity, spatial resolution, and timing characteristics. Energy resolution characteristics of the new detector were also investigated. The goal of the Phase II project is to advance the promising solid-state detector technology for small animal PET and determine its fullmore » potential. Detectors modules will be built and characterized and finally, a bench-top small animal PET system will be assembled and evaluated.« less
Authors:
Publication Date:
OSTI Identifier:
900321
Report Number(s):
DOE/ER/84298
C06-16; TRN: US0703515
DOE Contract Number:
FG02-05ER84298
Resource Type:
Technical Report
Research Org:
Radiation Monitoring Devices, Inc.
Sponsoring Org:
DOE
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; 46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND TECHNOLOGY; 72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS; 73 NUCLEAR PHYSICS AND RADIATION PHYSICS; ANIMALS; AUTORADIOGRAPHY; DESIGN; DISEASES; ENERGY RESOLUTION; IN VIVO; LABORATORY ANIMALS; PERFORMANCE; POSITRONS; RESOLUTION; SENSITIVITY; SPATIAL RESOLUTION; TOMOGRAPHY detector, positron, imaging, gamma-ray, high resolution