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Title: DNA Double-Strand Breaks, Chromosomal Rearrangements, and GenomicInstability

DNA double-strand breaks can lead to chromosomalrearrangements at the first mitosis after exposure to the DNAstrand-breaking agent. The evidence suggests a number of differentpathways for DNA double-strand break rejoining in mammalian cells, but itis unclear what factors determine the fate of the induced break andwhether or not it will lead to chromosomal rearrangement. If a cell doessurvive and proliferate after DNA cleavage, delayed chromosomalinstability can be observedin the clonal descendants of the exposedcell. Most, but not all DNA double-strand breaking agents are effectiveat inducing this delayed chromosomal instability. In this paper, wereview the evidence for the role of the DNA double-strand break indirectly induced and delayed chromosomal rearrangements. Copyright 1998Elsevier Science B.V.
Authors:
; ; ; ; ;
Publication Date:
OSTI Identifier:
895509
Report Number(s):
LBNL--41529
DOE Contract Number:
DE-AC02-05CH11231
Resource Type:
Journal Article
Resource Relation:
Journal Name: Mutation Research; Journal Volume: 404; Journal Issue: 1-2; Related Information: Journal Publication Date: 08/03/1998
Research Org:
Ernest Orlando Lawrence Berkeley NationalLaboratory, Berkeley, CA (US)
Sponsoring Org:
USDOE Director, Office of Energy Research
Country of Publication:
United States
Language:
English