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Title: Radiopharmaceutical Tracers for Neural Progenitor Cells

Abstract

The Technical Report summarizes the results of the synthesis and microPET animal scanning of several compounds labeled with positron-emitting isotopes in normal, neonatal and kainic acid treated (seizure induced) rats as potential PET tracers to image the process of neurogenesis using positron emission tomography (PET). The tracers tested were 3'-deoxy-3'-[F-18]fluorothymidine ([F-18]FLT) and 5'-benzoyl-FTL, 1-(2'-deoxy-2'-[F-18]fluoro-B-D-arabinofuranosyl)-5-bromouracil (FBAU) and 3',5'-dibenzoyl-FBAU, N-[F-18]fluoroacetyl-D-glucosamine (FLAG) and tetraacetyl-FLAG, and L-[1-C-11]leucine.

Authors:
Publication Date:
Research Org.:
Wayne State University, Detroit, MI; Children's Hospitall of Michigan, Detroit, MI
Sponsoring Org.:
USDOE Office of Science (SC)
OSTI Identifier:
892567
Report Number(s):
DOE/ER63607
TRN: US0703172
DOE Contract Number:  
FG02-03ER63607
Resource Type:
Technical Report
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; ANIMALS; POSITRONS; RADIOPHARMACEUTICALS; SYNTHESIS; TOMOGRAPHY; PET; Positron Emission Tomography; microPET; PET Radiopharmaceuticals; Neural Progenitor Cells; Neurogenesis

Citation Formats

Mangner, Thomas J. Radiopharmaceutical Tracers for Neural Progenitor Cells. United States: N. p., 2006. Web. doi:10.2172/892567.
Mangner, Thomas J. Radiopharmaceutical Tracers for Neural Progenitor Cells. United States. https://doi.org/10.2172/892567
Mangner, Thomas J. 2006. "Radiopharmaceutical Tracers for Neural Progenitor Cells". United States. https://doi.org/10.2172/892567. https://www.osti.gov/servlets/purl/892567.
@article{osti_892567,
title = {Radiopharmaceutical Tracers for Neural Progenitor Cells},
author = {Mangner, Thomas J},
abstractNote = {The Technical Report summarizes the results of the synthesis and microPET animal scanning of several compounds labeled with positron-emitting isotopes in normal, neonatal and kainic acid treated (seizure induced) rats as potential PET tracers to image the process of neurogenesis using positron emission tomography (PET). The tracers tested were 3'-deoxy-3'-[F-18]fluorothymidine ([F-18]FLT) and 5'-benzoyl-FTL, 1-(2'-deoxy-2'-[F-18]fluoro-B-D-arabinofuranosyl)-5-bromouracil (FBAU) and 3',5'-dibenzoyl-FBAU, N-[F-18]fluoroacetyl-D-glucosamine (FLAG) and tetraacetyl-FLAG, and L-[1-C-11]leucine.},
doi = {10.2172/892567},
url = {https://www.osti.gov/biblio/892567}, journal = {},
number = ,
volume = ,
place = {United States},
year = {Fri Sep 29 00:00:00 EDT 2006},
month = {Fri Sep 29 00:00:00 EDT 2006}
}