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Title: Investigation of near infrared autofluorescence imaging for the detection of breast cancer

Detection of breast cancer in fresh tissue obtained from surgery is investigated using Near-infrared autofluorescence imaging under laser excitation at 532-nm and 632.8-nm. The differences in intensity between the three main components of breast tissue (cancer, fibrous and adipose) are estimated and compared to those obtained from cross-polarized light scattering images recorded under polarized illumination at 700-nm. The optical spectroscopic images for each tissue sample were subsequently compared with the histopathology slides. The experimental results indicate that the intensity of the near-infrared emission is considerably different in breast cancer compared to that of the adjacent non-neoplastic tissues (adipose and fibrous tissue). The experimental results suggest that 632.8-nm excitation offers key advantages compared to 532-nm excitation.
Authors:
; ; ;
Publication Date:
OSTI Identifier:
891706
Report Number(s):
UCRL-JRNL-214764
TRN: US200622%%312
DOE Contract Number:
W-7405-ENG-48
Resource Type:
Journal Article
Resource Relation:
Journal Name: Journal of Selected Topics in Quantum Electronics, vol. 11, no. 4, November 2, 2005, pp. 791-798
Research Org:
Lawrence Livermore National Laboratory (LLNL), Livermore, CA
Sponsoring Org:
USDOE
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; DETECTION; EXCITATION; ILLUMINANCE; LASERS; LIGHT SCATTERING; MAMMARY GLANDS; NEOPLASMS; SURGERY