Nanoparticle Labels/ Electrochemical Immunosensor for Detection of Biomarkers
Conference
·
OSTI ID:888704
A sensitive electrochemical immunosensor based on poly(guanine) functionalized silica nanoparticle label has been developed for the detection of protein biomarker, biomarker recombinant human tumor necrosis factor-a(TNF-a).This method is simple, selective, and reproducible for trace biomarker analysis. A remarkable LOD has been achieved through dual signal amplification by poly[G] functionalized silica NPs and catalytic guanine oxidation. The work demonstrates the feasibility of developing an inexpensive, sensitive, and portable device for multiplexed diagnoses of different protein biomarkers.
- Research Organization:
- Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
- Sponsoring Organization:
- USDOE
- DOE Contract Number:
- AC05-76RL01830
- OSTI ID:
- 888704
- Report Number(s):
- PNNL-SA-49687; TRN: US200618%%383
- Resource Relation:
- Conference: Nanotech 2006 Technical Proceedings of the 2006 NSTI Nanotechnology Conference and Trade Show, 2(192-195
- Country of Publication:
- United States
- Language:
- English
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