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Title: Activated recombinant adenovirus proteinases

This application describes methods and expression constructs for producing activatable recombinant adenovirus proteinases. Purified activatable recombinant adenovirus proteinases and methods of purification are described. Activated adenovirus proteinases and methods for obtaining activated adenovirus proteinases are further included. Isolated peptide cofactors of adenovirus proteinase activity, methods of purifying and identifying said peptide cofactors are also described. Antibodies immunoreactive with adenovirus proteinases, immunospecific antibodies, and methods for preparing them are also described. Other related methods and materials are also described.
Authors:
 [1] ;  [2]
  1. (Stony Brook, NY)
  2. (Shoreham, NY)
Publication Date:
OSTI Identifier:
872441
Report Number(s):
US 5935840
US patent application 08/435,998
Resource Type:
Patent
Research Org:
Brookhaven National Laboratory (BNL), Upton, NY
Country of Publication:
United States
Language:
English
Subject:
activated; recombinant; adenovirus; proteinases; application; describes; methods; expression; constructs; producing; activatable; recombinant; adenovirus; proteinases; purified; activatable; recombinant; adenovirus; proteinases; methods; purification; described; activated; adenovirus; proteinases; methods; obtaining; activated; adenovirus; proteinases; included; isolated; peptide; cofactors; adenovirus; proteinase; activity; methods; purifying; identifying; peptide; cofactors; described; antibodies; immunoreactive; adenovirus; proteinases; immunospecific; antibodies; methods; preparing; described; related; methods; materials; described; related method; recombinant adenovirus; recombinant adenovirus; recombinant adenovirus; application describes; adenovirus proteinases; adenovirus proteinases; adenovirus proteinases; adenovirus proteinases; adenovirus proteinases; adenovirus proteinases; related methods; antibodies immunoreactive; isolated peptide; expression constructs; activatable recombinant; activatable recombinant; purified activatable; describes methods; producing activatable; activated recombinant; adenovirus proteinase; adenovirus proteinase; adenovirus proteinase; adenovirus proteinase; adenovirus proteinase; adenovirus proteinase; adenovirus proteinase /435/999/