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Title: Plant rhamnogalacturonan II complexation of heavy metal cations

The present invention provides rhamnogalacturonan-II (RG-II) and relates to its ability to complex specific multivalent heavy metal cations. In the presence of boric acid, RG-II monomers form dimers that are cross-linked by a borate ester. The yield of such borate ester cross-linked dimers of RG-II is enhanced in the presence of specific heavy metal cations. The present invention further relates to the utility of RG-II in assays for the detection of specific heavy metal contamination; as a reagent useful in the removal of specific heavy metal cations contaminating foods and liquids, for example, fish, wines, etc.; as a pharmaceutical composition useful as an antidote in specific heavy metal cation poisoning; as a treatment for the detoxification of specific heavy metal cations from blood and/or tissues; and in a method of remediation of waters and soils contaminated with specific heavy metal cations.
Authors:
 [1] ;  [2] ;  [3] ;  [4] ;  [3] ;  [3]
  1. (Winterville, GA)
  2. (Montpellier, FR)
  3. (Athens, GA)
  4. (Combaillaux, FR)
Publication Date:
OSTI Identifier:
872172
Report Number(s):
US 5877164
DOE Contract Number:
FG02-93ER20097; FG05-93ER20115
Resource Type:
Patent
Research Org:
University of Georgia; University of Georgia Research Foundation
Sponsoring Org:
USDOE
Country of Publication:
United States
Language:
English
Subject:
plant; rhamnogalacturonan; ii; complexation; heavy; metal; cations; provides; rhamnogalacturonan-ii; rg-ii; relates; ability; complex; specific; multivalent; presence; boric; acid; monomers; form; dimers; cross-linked; borate; ester; yield; enhanced; utility; assays; detection; contamination; reagent; useful; removal; contaminating; foods; liquids; example; fish; wines; etc; pharmaceutical; composition; antidote; cation; poisoning; treatment; detoxification; blood; tissues; method; remediation; waters; soils; contaminated; metal contamination; metal cations; heavy metal; boric acid; composition useful; pharmaceutical composition; soils contaminated; metal cation; form dimers; /514/436/999/