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Title: Derivatized gold clusters and antibody-gold cluster conjugates

Antibody- or antibody fragment-gold cluster conjugates are shown wherein the conjugate size can be as small as 5.0 nm. Methods and reagents are disclosed in which antibodies, Fab' or F(ab').sub.2 fragments thereof are covalently bound to a stable cluster of gold atoms. The gold clusters may contain 6, 8, 9, 11, 13, 55 or 67 gold atoms in their inner core. The clusters may also contain radioactive gold. The antibody-cluster conjugates are useful in electron microscopy applications as well as in clinical applications that include imaging, diagnosis and therapy.
Authors:
 [1] ;  [2]
  1. (Shoreham, NY)
  2. (Williston Park, NY)
Publication Date:
OSTI Identifier:
869590
Report Number(s):
US 5360895
US patent application 07/988,338
DOE Contract Number:
AC02-76CH00016
Resource Type:
Patent
Research Org:
ASSOC UNIVERSITIES INC
Country of Publication:
United States
Language:
English
Subject:
derivatized; gold; clusters; antibody-gold; cluster; conjugates; antibody-; antibody; fragment-gold; cluster; conjugates; shown; conjugate; size; nm; methods; reagents; disclosed; antibodies; fab; fragments; covalently; bound; stable; cluster; gold; atoms; gold; clusters; contain; 11; 13; 55; 67; gold; atoms; inner; core; clusters; contain; radioactive; gold; antibody-cluster; conjugates; useful; electron; microscopy; applications; clinical; applications; imaging; diagnosis; therapy; inner core; covalently bound; antibody fragment; cluster conjugates; cluster conjugates; cluster conjugates; electron microscopy /530/436/