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Title: Electromagnetic field triggered drug and chemical delivery via liposomes

The present invention relates to a system and to a method of delivering a drug to a preselected target body site of a patient, comprising the steps of encapsulating the chemical agent within liposomes, essentially temperature insensitive, i.e. not having a specific predetermined phase transition temperature within the specific temperature range of drug administration; administering the liposomes to the target body site; and subjecting the target body site to nonionizing electromagnetic fields in an area of the preselected target body in order to release said chemical agent from the liposomes at a temperature of between about +10 and 65.degree. C. The invention further relates to the use of said liposomes to bind to the surface of or to enter target tissue or an organ in a living system, and, when subjected to a nonionizing field, to release a drug from the liposomes into the target site.
Authors:
 [1]
  1. (1820 Mountain View Rd., Tiburon, CA 94920)
Publication Date:
OSTI Identifier:
868683
Report Number(s):
US 5190761
DOE Contract Number:
AC03-76SF00098
Resource Type:
Patent
Research Org:
Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA
Country of Publication:
United States
Language:
English
Subject:
electromagnetic; field; triggered; drug; chemical; delivery; via; liposomes; relates; method; delivering; drug; preselected; target; site; patient; comprising; steps; encapsulating; chemical; agent; liposomes; essentially; temperature; insensitive; specific; predetermined; phase; transition; temperature; specific; temperature; range; drug; administration; administering; liposomes; target; site; subjecting; target; site; nonionizing; electromagnetic; fields; preselected; target; release; chemical; agent; liposomes; temperature; 10; 65; degree; relates; liposomes; bind; surface; enter; target; tissue; organ; living; subjected; nonionizing; field; release; drug; liposomes; target; site; target tissue; chemical agent; chemical agent; ionizing electromagnetic; electromagnetic fields; electromagnetic field; electromagnetic field; temperature range; magnetic field; magnetic field; magnetic fields; transition temperature; phase transition; chemical delivery; target site; selected target; selected target; temperature insensitive /424/264/428/436/514/607/