skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Electromagnetic field triggered drug and chemical delivery via liposomes

Patent ·
OSTI ID:868683
 [1]
  1. 1820 Mountain View Rd., Tiburon, CA 94920
+ Show Author Affiliations

The present invention relates to a system and to a method of delivering a drug to a preselected target body site of a patient, comprising the steps of encapsulating the chemical agent within liposomes, essentially temperature insensitive, i.e. not having a specific predetermined phase transition temperature within the specific temperature range of drug administration; administering the liposomes to the target body site; and subjecting the target body site to nonionizing electromagnetic fields in an area of the preselected target body in order to release said chemical agent from the liposomes at a temperature of between about +10 and 65.degree. C. The invention further relates to the use of said liposomes to bind to the surface of or to enter target tissue or an organ in a living system, and, when subjected to a nonionizing field, to release a drug from the liposomes into the target site.

Research Organization:
Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)
DOE Contract Number:
AC03-76SF00098
Assignee:
Liburdy, Robert P. (1820 Mountain View Rd., Tiburon, CA 94920)
Patent Number(s):
US 5190761
OSTI ID:
868683
Country of Publication:
United States
Language:
English

References (10)

Treatment of Murine SCC VII Tumors with Localized Hyperthermia and Temperature-Sensitive Liposomes Containing Cisplatin journal May 1990
Microwaves and the Cell Membrane: II. Temperature, Plasma, and Oxygen Mediate Microwave-Induced Membrane Permeability in the Erythrocyte journal May 1985
Studies on lecithin-cholesterol-water interactions by differential scanning calorimetry and X-ray diffraction journal April 1968
Highly efficient DNA delivery mediated by pH-sensitive immunoliposomes journal November 1989
The effect of cholesterol incorporation on the temperature dependence of water permeation through liposomal membranes prepared from phosphatidylcholines journal February 1977
Design of liposomes for enhanced local release of drugs by hyperthermia journal December 1978
Effect of 2.45 GHz microwave radiation on permeability of unilamellar liposomes to 5(6)-carboxyfluorescein. Evidence of non-thermal leakage journal April 1991
Hyperthermia and Cancer book January 1982
Liposomes and local hyperthermia: selective delivery of methotrexate to heated tumors journal April 1979
Microwave-Stimulated Drug Release from Liposomes journal August 1985

Similar Records

Electromagnetic field triggered drug and chemical delivery via liposomes
Patent · Tue Mar 02 00:00:00 EST 1993 · OSTI ID:868683
Assessment of laser-induced release of drugs from liposomes: An in vitro study
Journal Article · Mon Jan 01 00:00:00 EST 1990 · Lasers in Surgery and Medicine; (USA) · OSTI ID:868683
Feasibility of targeted drug delivery to selective areas of the retina
Journal Article · Mon Jul 01 00:00:00 EDT 1991 · Investigative Ophthalmology and Visual Science; (United States) · OSTI ID:868683
+2 more

Related Subjects

electromagnetic
field
triggered
drug
chemical
delivery
via
liposomes
relates
method
delivering
preselected
target
site
patient
comprising
steps
encapsulating
agent
essentially
temperature
insensitive
specific
predetermined
phase
transition
range
administration
administering
subjecting
nonionizing
fields
release
10
65
degree
bind
surface
enter
tissue
organ
living
subjected
target tissue
chemical agent
ionizing electromagnetic
electromagnetic fields
electromagnetic field
temperature range
magnetic field
magnetic fields
transition temperature
phase transition
chemical delivery
target site
selected target
temperature insensitive
/424/264/428/436/514/607/