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Title: Low toxicity method of inhibiting sickling of sickle erythrocytes

A low toxicity method of inhibiting sickling of sickle erythrocytes which comprises intermixing the erythrocytes with an effective anti-sickling amount of a water-soluble imidoester of the formula RC(=NH)OR' wherein R is an alkyl group of 1 - 8 carbon atoms, particularly 1 - 4 carbon atoms, and R' is an alkyl group of 1 - 4 carbon atoms, specifically methyl or ethyl acetimidate.
Authors:
 [1] ;  [2]
  1. (Orinda, CA)
  2. (Oakland, CA)
Publication Date:
OSTI Identifier:
862920
Report Number(s):
US 4048325
DOE Contract Number:
W-7405-ENG-48
Resource Type:
Patent
Research Org:
Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)
Country of Publication:
United States
Language:
English
Subject:
toxicity; method; inhibiting; sickling; sickle; erythrocytes; comprises; intermixing; effective; anti-sickling; amount; water-soluble; imidoester; formula; nh; alkyl; carbon; atoms; particularly; specifically; methyl; ethyl; acetimidate; carbon atoms; carbon atom; sickle erythrocytes; toxicity method; inhibiting sickling; /514/435/