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Title: Semiconductor Nanocrystals for Biological Imaging

Conventional organic fluorophores suffer from poor photo stability, narrow absorption spectra and broad emission feature. Semiconductor nanocrystals, on the other hand, are highly photo-stable with broad absorption spectra and narrow size-tunable emission spectra. Recent advances in the synthesis of these materials have resulted in bright, sensitive, extremely photo-stable and biocompatible semiconductor fluorophores. Commercial availability facilitates their application in a variety of unprecedented biological experiments, including multiplexed cellular imaging, long-term in vitro and in vivo labeling, deep tissue structure mapping and single particle investigation of dynamic cellular processes. Semiconductor nanocrystals are one of the first examples of nanotechnology enabling a new class of biomedical applications.
Authors:
; ; ;
Publication Date:
OSTI Identifier:
861264
Report Number(s):
LBNL--57928
R&D Project: M50013; BnR: 600305000; TRN: US200601%%754
DOE Contract Number:
DE-AC02-05CH11231; NIH:0980GCD709
Resource Type:
Journal Article
Resource Relation:
Journal Name: Current Opinion in Neurobiology; Journal Volume: 15; Journal Issue: 5; Related Information: Journal Publication Date: 10/2005
Research Org:
Ernest Orlando Lawrence Berkeley NationalLaboratory, Berkeley, CA (US)
Sponsoring Org:
USDOE; National Institutes of Health. National Center forResearch Resources Agreement 0980GCF709, Department of Defense. BreastCancer Research progam DAMD17-03-1-9637, US Defense Advanced ResearchProject Agency. Air Force Office of Scientific Research. DefenseUniversity Research Initiative on Nanotechnology Program GrantF49620-01-1-0474
Country of Publication:
United States
Language:
English
Subject:
36 MATERIALS SCIENCE; 37 INORGANIC, ORGANIC, PHYSICAL AND ANALYTICAL CHEMISTRY; ABSORPTION SPECTRA; AVAILABILITY; EMISSION SPECTRA; IN VITRO; IN VIVO; STABILITY; SYNTHESIS Semiconductor nanocrystals quantum dots fluorescent probeimaging