Synthesis and characterization of multiply-tyrosinated, multiply-iodinated somatostatin analogs

Journal Article · Mon Feb 01 00:00:00 EST 1999 · Journal of Peptide Research

DOI:https://doi.org/10.1111/j.1397-002X.1999.00019.x· OSTI ID:860139

Woltering, E A; O'Dorisio, M S; Murphy, W A; Chen, F; Drouant, G J; Espenan, G D; Fisher, Darrell R; Sharma, C; Diaco, D S; Maloney, T M; Fuselier, J A; Nelson, J A; O'Dorisio, T M; Coy, D H

Radio-labeled somatostatin analogs have recently gained popularity as agents useful in intraoperative tumor localization, external scintigraphy and in situ radiotherapy. We have synthesized and characterized a series of novel N-terminally extended multiply-tyrosinated somatostatin analogs that possess high binding affinity for somatostatin receptors, exhibit biological activity comparable to the native peptide and retain these characteristics after iodination. These analogs can be radio-iodinated to high specific activities. Following radio-iodination, these analogs exhibit minimal radiolysis and may be clinically useful for tumor localization, scanning and therapy.

• Research Organization: Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
• Sponsoring Organization: USDOE
• DOE Contract Number: AC05-76RL01830
• OSTI ID: 860139
• Report Number(s): PNWD-SA-4658; TRN: US0504855
• Journal Information: Journal of Peptide Research, Vol. 53, Issue 2
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
AFFINITY
IODINATION
NEOPLASMS
PEPTIDES
RADIOLYSIS
RADIOTHERAPY
SCINTISCANNING
SOMATOSTATIN
SYNTHESIS
THERAPY
growth hormone
neuroblastoma
in situ radiotherapy
pituitary cells
radiation
scintigraphy
somat