Synthesis and characterization of multiply-tyrosinated, multiply-iodinated somatostatin analogs
Journal Article
·
· Journal of Peptide Research
Radio-labeled somatostatin analogs have recently gained popularity as agents useful in intraoperative tumor localization, external scintigraphy and in situ radiotherapy. We have synthesized and characterized a series of novel N-terminally extended multiply-tyrosinated somatostatin analogs that possess high binding affinity for somatostatin receptors, exhibit biological activity comparable to the native peptide and retain these characteristics after iodination. These analogs can be radio-iodinated to high specific activities. Following radio-iodination, these analogs exhibit minimal radiolysis and may be clinically useful for tumor localization, scanning and therapy.
- Research Organization:
- Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
- Sponsoring Organization:
- USDOE
- DOE Contract Number:
- AC05-76RL01830
- OSTI ID:
- 860139
- Report Number(s):
- PNWD-SA-4658; TRN: US0504855
- Journal Information:
- Journal of Peptide Research, Vol. 53, Issue 2
- Country of Publication:
- United States
- Language:
- English
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