Studying cellular processes and detecting disease with protein microarrays

Journal Article · Mon Oct 31 00:00:00 EST 2005 · Drug Metabolism Reviews

DOI:https://doi.org/10.1080/03602530500205309· OSTI ID:859982

Zangar, Richard C; Varnum, Susan M; Bollinger, Nikki

Protein microarrays are a rapidly developing analytic tool with diverse applications in biomedical research. These applications include profiling of disease markers or autoimmune responses, understanding molecular pathways, protein modifications and protein activities. One factor that is driving this expanding usage is the wide variety of experimental formats that protein microarrays can take. In this review, we provide a short, conceptual overview of the different approaches for protein microarray. We then examine some of the most significant applications of these microarrays to date, with an emphasis on how global protein analyses can be used to facilitate biomedical research.

• Research Organization: Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
• Sponsoring Organization: USDOE
• DOE Contract Number: AC05-76RL01830
• OSTI ID: 859982
• Report Number(s): PNNL-SA-46072; 400412000; TRN: US200523%%146
• Journal Information: Drug Metabolism Reviews, Vol. 37, Issue 3
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
DISEASES
MODIFICATIONS
PROTEINS
ELISA microarrays