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Title: Locus Adh of Drosophila melanogaster under selection for delayed senescence

Abstract

Dynamics of the Adh activity and frequencies of alleles Adh{sup F} and Adh{sup S} were analyzed under selection for delayed senescence. The experiments were performed on Drosophila melanogaster. Lines Adh{sup S}cn and Adh{sup F}vg and experimental populations cn` and vg`, selected for an increased duration of reproductive period (late oviposition) were used. Analysis of fertility, longevity, viability and resistance to starvation showed that selection for late oviposition resulted in delayed senescence of flies of the experimental populations. Genetic structure of population vg` changed considerably with regard to the Adh locus. This was confirmed by parameters of activity, thermostability, and electrophoretic mobility of the enzyme isolated from flies after 30 generations of selection. Analysis of frequencies of the Adh alleles showed that in both selected populations, which initially had different genetic composition, accumulated allele Adh{sup S}, which encodes the isozyme that is less active but more resistant to inactivation. Genetic mechanism of delayed senescence in Drosophila is assumed to involve selection at vitally important enzyme loci, including Adh. 18 refs., 2 tabs., 4 figs.

Authors:
 [1]
  1. Odessa State Univ. (Ukraine)
Publication Date:
OSTI Identifier:
83490
Resource Type:
Journal Article
Journal Name:
Russian Journal of Genetics
Additional Journal Information:
Journal Volume: 31; Journal Issue: 5; Other Information: PBD: May 1995; TN: Translated from Genetika; 31: No. 5, 646-651(1995)
Country of Publication:
United States
Language:
English
Subject:
55 BIOLOGY AND MEDICINE, BASIC STUDIES; DROSOPHILA; AGING; REPRODUCTION; GENES; STRUCTURE-ACTIVITY RELATIONSHIPS; ENZYMES; CHROMOSOMES

Citation Formats

Khaustova, N D. Locus Adh of Drosophila melanogaster under selection for delayed senescence. United States: N. p., 1995. Web.
Khaustova, N D. Locus Adh of Drosophila melanogaster under selection for delayed senescence. United States.
Khaustova, N D. 1995. "Locus Adh of Drosophila melanogaster under selection for delayed senescence". United States.
@article{osti_83490,
title = {Locus Adh of Drosophila melanogaster under selection for delayed senescence},
author = {Khaustova, N D},
abstractNote = {Dynamics of the Adh activity and frequencies of alleles Adh{sup F} and Adh{sup S} were analyzed under selection for delayed senescence. The experiments were performed on Drosophila melanogaster. Lines Adh{sup S}cn and Adh{sup F}vg and experimental populations cn` and vg`, selected for an increased duration of reproductive period (late oviposition) were used. Analysis of fertility, longevity, viability and resistance to starvation showed that selection for late oviposition resulted in delayed senescence of flies of the experimental populations. Genetic structure of population vg` changed considerably with regard to the Adh locus. This was confirmed by parameters of activity, thermostability, and electrophoretic mobility of the enzyme isolated from flies after 30 generations of selection. Analysis of frequencies of the Adh alleles showed that in both selected populations, which initially had different genetic composition, accumulated allele Adh{sup S}, which encodes the isozyme that is less active but more resistant to inactivation. Genetic mechanism of delayed senescence in Drosophila is assumed to involve selection at vitally important enzyme loci, including Adh. 18 refs., 2 tabs., 4 figs.},
doi = {},
url = {https://www.osti.gov/biblio/83490}, journal = {Russian Journal of Genetics},
number = 5,
volume = 31,
place = {United States},
year = {Mon May 01 00:00:00 EDT 1995},
month = {Mon May 01 00:00:00 EDT 1995}
}