Imidazole derivatives. XXVII. Synthesis and radioprotective activity of substituted phenacylthioimidazoline and 3-phenyl-5,6-dihydroimidazo[2,1-B]thiazole hydrochlorides
Journal Article
·
· Pharmaceutical Chemistry Journal
OSTI ID:83466
- and others
Previously, we described the synthesis of phenacylthioimidazolines and investigated the biological properties of the corresponding hydrochlorides. It was found that some hydorchlorides exhibited quite significant sympathicolytic and mutagenic activity. Due to the low solubility of substituted phenacylthioimidazoline hydrobromides in water and the fact that they can cyclize into imidazothiazoles it was difficult to convert the hydrobromides to the corresponding hydrochlorides. For this reason the phenacylthioimidazoline hydrochlorides were synthesized in the present work by reacting the phenacyl chlorides with 2-thio-2-imidazoline. 8 refs., 2 figs., 2 tabs.
- OSTI ID:
- 83466
- Journal Information:
- Pharmaceutical Chemistry Journal, Vol. 28, Issue 7; Other Information: PBD: May 1995; TN: Translated from Khimiko-farmatsevticheskii Zhurnal; 28: No. 7, 13-15(Jul 1994)
- Country of Publication:
- United States
- Language:
- English
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