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Title: NMR studies of isotopically labeled RNA

In summary, the ability to generate NMR quantities of {sup 15}N and {sup 13}C-labeled RNAs has led to the development of heteronuclear multi-dimensional NMR techniques for simplifying the resonance assignment and structure determination of RNAs. These methods for synthesizing isotopically labeled RNAs are only several years old, and thus there are still relatively few applications of heteronuclear multi-dimensional NMR techniques to RNA. However, given the critical role that RNAs play in cellular function, one can expect to see an increasing number of NMR structural studies of biologically active RNAs.
Authors:
 [1]
  1. Univ. of Colorado, Boulder, CO (United States)
Publication Date:
OSTI Identifier:
83382
Report Number(s):
LA-12893-C; CONF-9403228-
ON: DE95012795; TRN: 95:004732-0013
Resource Type:
Conference
Resource Relation:
Conference: Stable isotope applications in biomolecular structure and mechanisms, Santa Fe, NM (United States), 27-31 Mar 1994; Other Information: PBD: Dec 1994; Related Information: Is Part Of Stable isotope applications in biomolecular structure and mechanisms. A meeting to bring together producers and users of stable-isotope-labeled compounds to assess current and future needs; Trewhella, J.; Cross, T.A.; Unkefer, C.J. [eds.]; PB: 382 p.
Research Org:
Los Alamos National Lab., NM (United States)
Country of Publication:
United States
Language:
English
Subject:
55 BIOLOGY AND MEDICINE, BASIC STUDIES; 40 CHEMISTRY; RNA; NMR IMAGING; MOLECULAR STRUCTURE; ISOTOPE APPLICATIONS; NUCLEAR MAGNETIC RESONANCE; LABELLING; NITROGEN 15; CARBON 13