Polarity determination in breast tissue: Desmosomal adhesion, myoepit helial cells, and laminin 1
Journal Article
·
· The Breast Cancer Journal
OSTI ID:816540
In all epithelial organs, apicobasal polarity determines functional integrity and contributes to the maintenance of tissue and organ specificity. In the breast, the functional unit is a polar double-layered tube consisting of luminal epithelial cells surrounded by myoepithelial cells and a basement membrane. It is far from clear how this double-layered structure is established and how polarity is maintained. Two recent papers have shed some light onto this intriguing problem in mammary gland biology. The results point to desmosomes and laminin 1 as having crucial roles. However, some questions remain.
- Research Organization:
- Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
- Sponsoring Organization:
- USDOE Director, Office of Science. Office of Biological and Environmental Research. Life Sciences Division (US)
- DOE Contract Number:
- AC03-76SF00098
- OSTI ID:
- 816540
- Report Number(s):
- LBNL-52880; R&D Project: 443180; TRN: US200320%%627
- Journal Information:
- The Breast Cancer Journal, Vol. 5, Issue 2; Other Information: Journal Publication Date: 2003; PBD: 5 Jun 2003
- Country of Publication:
- United States
- Language:
- English
Similar Records
Normal and tumor-derived myoepithelial cells differ in their ability to interact with luminal breast epithelial cells for polarity and basement membrane deposition
Processing of Human Reduction Mammoplasty and Mastectomy Tissues for Cell Culture
Expression of Autoactivated Stromelysin-1 in Mammary Glands of Transgenic Mice Leads to a Reactive Stroma During Early Development
Journal Article
·
Thu Oct 04 00:00:00 EDT 2001
· Journal of Cell Science
·
OSTI ID:816540
+3 more
Processing of Human Reduction Mammoplasty and Mastectomy Tissues for Cell Culture
Journal Article
·
Thu Jan 03 00:00:00 EST 2013
· Journal of Visualized Experiments
·
OSTI ID:816540
Expression of Autoactivated Stromelysin-1 in Mammary Glands of Transgenic Mice Leads to a Reactive Stroma During Early Development
Journal Article
·
Fri Apr 24 00:00:00 EDT 1998
· American Journal of Pathology
·
OSTI ID:816540
+5 more