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Title: A new approach to mineralization of biocompatible hydrogel scaffolds: An efficient process towards 3-dimensional bonelike composites

Abstract

As a first step toward the design and fabrication of biomimetic bonelike composite materials, we have developed a template-driven nucleation and mineral growth process for the high-affinity integration of hydroxyapatite with a poly(2-hydroxyethyl methacrylate) (pHEMA) hydrogel scaffold. A mineralization technique was developed that exposes carboxylate groups on the surface of cross-linked pHEMA, promoting high-affinity nucleation and growth of calcium phosphate on the surface, along with extensive calcification of the hydrogel interior. Robust surface mineral layers a few microns thick were obtained. The same mineralization technique, when applied to a hydrogel that is less prone to surface hydrolysis, led to distinctly different mineralization patterns, in terms of both the extent of mineralization and the crystallinity of the apatite grown on the hydrogel surface. This template-driven mineralization technique provides an efficient approach toward bonelike composites with high mineral -hydrogel interfacial adhesion strength.

Authors:
; ;
Publication Date:
Research Org.:
Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
Sponsoring Org.:
Office of Science. Basic Energy Sciences (US)
OSTI Identifier:
813526
Report Number(s):
LBNL-52644
Journal ID: ISSN 0002-7863; JACSAT; R&D Project: 519055; TRN: US200316%%250
DOE Contract Number:  
AC03-76SF00098
Resource Type:
Journal Article
Journal Name:
Journal of the American Chemical Society
Additional Journal Information:
Journal Volume: 125; Journal Issue: 5; Other Information: Journal Publication Date: 2/5/2003; PBD: 16 Sep 2002; Journal ID: ISSN 0002-7863
Country of Publication:
United States
Language:
English
Subject:
36 MATERIALS SCIENCE; ADHESION; APATITES; CALCIUM PHOSPHATES; COMPOSITE MATERIALS; DESIGN; FABRICATION; HYDROLYSIS; MINERALIZATION; NUCLEATION

Citation Formats

Song, Jie, Saiz, Eduardo, and Bertozzi, Carolyn. A new approach to mineralization of biocompatible hydrogel scaffolds: An efficient process towards 3-dimensional bonelike composites. United States: N. p., 2002. Web.
Song, Jie, Saiz, Eduardo, & Bertozzi, Carolyn. A new approach to mineralization of biocompatible hydrogel scaffolds: An efficient process towards 3-dimensional bonelike composites. United States.
Song, Jie, Saiz, Eduardo, and Bertozzi, Carolyn. 2002. "A new approach to mineralization of biocompatible hydrogel scaffolds: An efficient process towards 3-dimensional bonelike composites". United States.
@article{osti_813526,
title = {A new approach to mineralization of biocompatible hydrogel scaffolds: An efficient process towards 3-dimensional bonelike composites},
author = {Song, Jie and Saiz, Eduardo and Bertozzi, Carolyn},
abstractNote = {As a first step toward the design and fabrication of biomimetic bonelike composite materials, we have developed a template-driven nucleation and mineral growth process for the high-affinity integration of hydroxyapatite with a poly(2-hydroxyethyl methacrylate) (pHEMA) hydrogel scaffold. A mineralization technique was developed that exposes carboxylate groups on the surface of cross-linked pHEMA, promoting high-affinity nucleation and growth of calcium phosphate on the surface, along with extensive calcification of the hydrogel interior. Robust surface mineral layers a few microns thick were obtained. The same mineralization technique, when applied to a hydrogel that is less prone to surface hydrolysis, led to distinctly different mineralization patterns, in terms of both the extent of mineralization and the crystallinity of the apatite grown on the hydrogel surface. This template-driven mineralization technique provides an efficient approach toward bonelike composites with high mineral -hydrogel interfacial adhesion strength.},
doi = {},
url = {https://www.osti.gov/biblio/813526}, journal = {Journal of the American Chemical Society},
issn = {0002-7863},
number = 5,
volume = 125,
place = {United States},
year = {Mon Sep 16 00:00:00 EDT 2002},
month = {Mon Sep 16 00:00:00 EDT 2002}
}