Effect of ozone exposure on antigen-induced airway hyperresponsiveness in guinea pigs
Abstract
Airway hyperresponsiveness can be induced by several stimuli including antigen and ozone, both of which may be present in the air of polluted cities. Though the effect of ozone on the bronchoconstrictor response to antigen has been well described, the combined effect of these stimuli on airway hyperresponsiveness has not yet been studied. Sensitized guinea pigs with or without ozone exposure for 1 h at 3 ppm, 18 h prior to study, were challenged with a dose-response curve to histamine (0.01-1.8 {mu}g/kg, iv), and then by a second histamine dose-response curve 1 h later. Airway responses were measured as the increase in pulmonary insufflation pressure. In sensitized guinea pigs, the histamine ED50 significantly decreased after antigen challenge, demonstrating the development of airway hyperresponsiveness. Sensitized guinea pigs exposed to ozone showed airway hyperresponsiveness to histamine when compared with nonexposed animals, and such hyperresponsiveness was further enhanced after antigen challenge. We conclude that in this guinea pig model of acute allergic bronchoconstriction both antigen challenge and ozone induce airway hyperresponsiveness, while ozone exposure does not modify the development of antigen-induced hyperresponsiveness. 25 refs., 1 fig., 1 tab.
- Authors:
- Publication Date:
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 81229
- Resource Type:
- Journal Article
- Journal Name:
- Journal of Toxicology and Environmental Health
- Additional Journal Information:
- Journal Volume: 42; Journal Issue: 4; Other Information: PBD: 1994
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 56 BIOLOGY AND MEDICINE, APPLIED STUDIES; 55 BIOLOGY AND MEDICINE, BASIC STUDIES; OZONE; BIOLOGICAL EFFECTS; BRONCHI; RESPONSE FUNCTIONS; ANTIGENS; GUINEA PIGS; HISTAMINE; ALLERGY; TOXICITY
Citation Formats
Vargas, M H, Segura, P, Campos, M G, Hong, E, and Montano, L M. Effect of ozone exposure on antigen-induced airway hyperresponsiveness in guinea pigs. United States: N. p., 1994.
Web. doi:10.1080/15287399409531893.
Vargas, M H, Segura, P, Campos, M G, Hong, E, & Montano, L M. Effect of ozone exposure on antigen-induced airway hyperresponsiveness in guinea pigs. United States. https://doi.org/10.1080/15287399409531893
Vargas, M H, Segura, P, Campos, M G, Hong, E, and Montano, L M. 1994.
"Effect of ozone exposure on antigen-induced airway hyperresponsiveness in guinea pigs". United States. https://doi.org/10.1080/15287399409531893.
@article{osti_81229,
title = {Effect of ozone exposure on antigen-induced airway hyperresponsiveness in guinea pigs},
author = {Vargas, M H and Segura, P and Campos, M G and Hong, E and Montano, L M},
abstractNote = {Airway hyperresponsiveness can be induced by several stimuli including antigen and ozone, both of which may be present in the air of polluted cities. Though the effect of ozone on the bronchoconstrictor response to antigen has been well described, the combined effect of these stimuli on airway hyperresponsiveness has not yet been studied. Sensitized guinea pigs with or without ozone exposure for 1 h at 3 ppm, 18 h prior to study, were challenged with a dose-response curve to histamine (0.01-1.8 {mu}g/kg, iv), and then by a second histamine dose-response curve 1 h later. Airway responses were measured as the increase in pulmonary insufflation pressure. In sensitized guinea pigs, the histamine ED50 significantly decreased after antigen challenge, demonstrating the development of airway hyperresponsiveness. Sensitized guinea pigs exposed to ozone showed airway hyperresponsiveness to histamine when compared with nonexposed animals, and such hyperresponsiveness was further enhanced after antigen challenge. We conclude that in this guinea pig model of acute allergic bronchoconstriction both antigen challenge and ozone induce airway hyperresponsiveness, while ozone exposure does not modify the development of antigen-induced hyperresponsiveness. 25 refs., 1 fig., 1 tab.},
doi = {10.1080/15287399409531893},
url = {https://www.osti.gov/biblio/81229},
journal = {Journal of Toxicology and Environmental Health},
number = 4,
volume = 42,
place = {United States},
year = {Sat Dec 31 00:00:00 EST 1994},
month = {Sat Dec 31 00:00:00 EST 1994}
}