GENETIC AND MOLECULAR ANALYSIS OF DNA DAMAGE REPAIR AND TOLERANCE PATHWAYS.
Radiation can damage cellular components, including DNA. Organisms have developed a panoply of means of dealing with DNA damage. Some repair paths have rather narrow substrate specificity (e.g. photolyases), which act on specific pyrimidine photoproducts in a specific type (e.g., DNA) and conformation (double-stranded B conformation) of nucleic acid. Others, for example, nucleotide excision repair, deal with larger classes of damages, in this case bulky adducts in DNA. A detailed discussion of DNA repair mechanisms is beyond the scope of this article, but one can be found in the excellent book of Friedberg et al.  for further detail. However, some DNA damages and paths for repair of those damages important for photobiology will be outlined below as a basis for the specific examples of genetic and molecular analysis that will be presented below.
- Publication Date:
- OSTI Identifier:
- Report Number(s):
- BNL-68537; KP1102020
R&D Project: BO086; KP1102020; TRN: AH200131%%107
- DOE Contract Number:
- Resource Type:
- Resource Relation:
- Other Information: BOOK TITLE: ENVIRONMENTAL RADIATION: IMPACT ON ECOSYSTEMS..., GHETTI,F.; PBD: 26 Jul 2001
- Brookhaven National Laboratory, Upton, NY (US)
- Research Org:
- Brookhaven National Lab., Upton, NY (US)
- Sponsoring Org:
- USDOE Office of Energy Research (ER) (US)
- Country of Publication:
- United States
- 59 BASIC BIOLOGICAL SCIENCES; DNA; DNA DAMAGES; DNA REPAIR; EXCISION REPAIR; GENETICS; NUCLEIC ACIDS; REPAIR; TOLERANCE
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