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Title: GENETIC AND MOLECULAR ANALYSIS OF DNA DAMAGE REPAIR AND TOLERANCE PATHWAYS.

Radiation can damage cellular components, including DNA. Organisms have developed a panoply of means of dealing with DNA damage. Some repair paths have rather narrow substrate specificity (e.g. photolyases), which act on specific pyrimidine photoproducts in a specific type (e.g., DNA) and conformation (double-stranded B conformation) of nucleic acid. Others, for example, nucleotide excision repair, deal with larger classes of damages, in this case bulky adducts in DNA. A detailed discussion of DNA repair mechanisms is beyond the scope of this article, but one can be found in the excellent book of Friedberg et al. [1] for further detail. However, some DNA damages and paths for repair of those damages important for photobiology will be outlined below as a basis for the specific examples of genetic and molecular analysis that will be presented below.
Authors:
Publication Date:
OSTI Identifier:
785050
Report Number(s):
BNL--68537; KP1102020
R&D Project: BO086; KP1102020; TRN: AH200131%%107
DOE Contract Number:
AC02-98CH10886
Resource Type:
Book
Resource Relation:
Other Information: BOOK TITLE: ENVIRONMENTAL RADIATION: IMPACT ON ECOSYSTEMS..., GHETTI,F.; PBD: 26 Jul 2001
Publisher:
Brookhaven National Laboratory, Upton, NY (US)
Research Org:
Brookhaven National Lab., Upton, NY (US)
Sponsoring Org:
USDOE Office of Energy Research (ER) (US)
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; DNA; DNA DAMAGES; DNA REPAIR; EXCISION REPAIR; GENETICS; NUCLEIC ACIDS; REPAIR; TOLERANCE