Synthesis of high specific activity [ethyl-1,2-3H]-labeled chlorpyrifos oxon and diazoxon

Journal Article · Mon May 01 00:00:00 EDT 2000 · Journal of Labelled Compounds and Radiopharmaceuticals

DOI:https://doi.org/10.1002/1099-1344(200011)43:13<1275::AID-JLCR416>3.3.CO;2-7· OSTI ID:779735

Zhang, Nanjing; Morimoto, Hiromi; Williams, Philip G; Casida, John E

[Ethyl-1,2-3H] Chlorpyrifos oxon and [ethyl-1,2-3H] diazoxon were synthesized at a specific activity of 79 and 58 Ci/mmol, respectively, by catalytic tritiation of the corresponding monovinyl analogs over Pd/C. Direct evidence is provided that the high specific activity results from isotope exchange of the terminal vinylic protons prior to saturation of the double bond. This radiosynthesis procedure is applicable to the toxicologically-important oxon metabolites of many commercial O-O-diethyl phosphorothioate pesticides.

• Research Organization: Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
• Sponsoring Organization: National Institutes of Health (US)
• DOE Contract Number: AC03-76SF00098
• OSTI ID: 779735
• Report Number(s): LBNL-45857; JLCRD4; R&D Project: 865036; TRN: US0102269
• Journal Information: Journal of Labelled Compounds and Radiopharmaceuticals, Vol. 43, Issue 13; Other Information: Journal Publication Date: Nov. 2000; PBD: 1 May 2000; ISSN 0362-4803
• Country of Publication: United States
• Language: English

Related Subjects

38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
DIAZO COMPOUNDS
ORGANIC CHLORINE COMPOUNDS
CHEMICAL PREPARATION
LABELLED COMPOUNDS
ISOTOPIC EXCHANGE
METABOLITES
PESTICIDES
TRITIUM
ACETYLCHOLINESTERASE CHLORPYRIFOS OXON DIAZOXON INSECTICIDE TRITIUM ISOTOPE EXCHANGE